Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

The role of pattern recognition receptors (PRR) in human candidiasis

(2014) The role of pattern recognition receptors (PRR) in human candidiasis. Journal of Mazandaran University of Medical Sciences.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Candida species are medically significant yeast that can cause different infection ranging from mild mucosal to disseminated infection. Invasive and sever mucosal infections are often life threatening disorders, especially in immunocompromised hosts due to immunodeficiency either in adaptive or innate immunity which are susceptible to candidiasis. Nevertheless, not all of them are susceptible to candidiasis which shows that genetic variation and polymorphism in immune system can play a crucial role in infection. Although genetic variation occurs rarely in human�s genome, it has a significant role in susceptibility to fungal infections. For example, genetic variation in coding genes of PRRs (TLR2, TLR4, Dectin I, Dectin II, and NLRp3) is correlated with susceptibility to candidiasis. Results have shown polymorphisms in genes that are involved in host defense against Candida infection. Therefore, genetic and immunological studies are highly necessary to understand the pathogenesis. Recently several studies have been performed on host defense against Candida infections which might be useful in the diagnosis and treatment of fungal infections. This paper represents a comprehensive overview of genetic susceptibility in human�s Candida infection. © 2014, Mazandaran University of Medical Sciences. All rights reserved.

Item Type: Article
Keywords: cryopyrin; dectin 1; dectin 2; pattern recognition receptor; toll like receptor 2; toll like receptor 4, Article; Candida; candidiasis; dectin I gene; dectin II gene; DNA polymorphism; gene; genetic susceptibility; genetic variability; human; NLRP3 gene; TLR2 gene; TLR4 gene
Page Range: pp. 224-240
Journal or Publication Title: Journal of Mazandaran University of Medical Sciences
Volume: 24
Number: 116
Publisher: Mazandaran University of Medical Sciences
ISSN: 17359279
Depositing User: مهندس جمال محمودپور
URI: http://eprints.muk.ac.ir/id/eprint/1034

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