Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Levels of mRNAs for membrane beta and gamma progesterone receptors in the fallopian tubes of women with ectopic pregnancy

(2014) Levels of mRNAs for membrane beta and gamma progesterone receptors in the fallopian tubes of women with ectopic pregnancy. Acta Endocrinologica.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Background. The transport of gametes and embryos is facilitated by motile cilia lining the inside of the fallopian tube. Progesterone regulates ciliary beat frequency (CBF) through multiple types of progesterone receptors in the fallopian tube. Membrane progesterone receptors beta and gamma (mPRβ and mPRγ) are both expressed in the ciliated cell lining of the fallopian tubes of humans. This study aimed at exploring the mRNA expression of mPRβ and mPRγ in the fallopian tubes of women with ectopic pregnancy. Materials and Methods. In this Case control study, a quantitative reverse transcriptase polymerase chain reaction was performed to determine the mRNA expression of mPRβ and mPRγ in the fallopian tubes obtained from 12 women with ectopic pregnancies, 12 women with normal pregnancies, and 12 healthy nonpregnant women in the luteal phase of their menstrual cycle. Results. It was indicated that mPRβ and mPRγ were expressed in the fallopian tube of the three groups of participants. However, the expression of mPRβ and mPRγ mRNA in the fallopian tube of women with ectopic pregnancy was not significantly different from that of the nonpregnant and normal pregnant women. Conclusion. These results suggest that mPRs might play no role in etiology of ectopic pregnancies associated with disturbed progesterone signalling.

Item Type: Article
Keywords: Ectopic pregnancy; Fallopian tube; mPRβ; mPRγ
Page Range: pp. 195-202
Journal or Publication Title: Acta Endocrinologica
Volume: 10
Number: 2
Publisher: Acta Endocrinologica Foundation
Identification Number: 10.4183/aeb.2014.195
ISSN: 18410987
Depositing User: مهندس جمال محمودپور
URI: http://eprints.muk.ac.ir/id/eprint/1043

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