(2014) Potential impact of air pollution on multiple sclerosis in Tehran, Iran. Neuroepidemiology.
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Abstract
Background: Multiple sclerosis (MS) incidence has dramatically increased in Tehran, Iran. The health impact of air pollution in Tehran underscores the attention to a possible association to this environmental risk factor. In this study, the authors aimed to analyze the spatial distribution of prevalent MS cases and their association with the spatial patterns of air pollution. Methods: Patient records meeting McDonald's criteria for definite MS diagnosis with disease onset during 2003-2013 were obtained. Next, the location of 2,188 patients was successfully geo-referenced within Tehran metropolis by geographic information system (GIS) bureau of Iran's post office based on their phone numbers. A cluster analysis was performed using the average nearest neighbor index (ANNI) and quadrat analysis. The long-term exposures of MS patients to particulate matter (PM<inf>10</inf>), sulfur dioxide (SO<inf>2</inf>), nitrogen oxide (NO), nitrogen dioxide (NO<inf>2</inf>), and nitrogen oxides (NOx) were estimated using the previously developed land use regression models. Results: Prevalent MS cases had a clustered pattern in Tehran. A significant difference in exposure to PM<inf>10</inf>, SO<inf>2</inf>, NO<inf>2</inf>, and NOx (p < 0.001) was observed in MS cases compared with controls. Conclusion: This study revealed the potential role of long-term exposure to air pollutants as an environmental risk factor in MS. © 2014 S. Karger AG, Basel.
Item Type: | Article |
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Keywords: | nitrogen dioxide; nitrogen oxide; sulfur dioxide, air pollution; Article; controlled study; environmental exposure; female; geographic information system; human; Iran; long term exposure; major clinical study; male; multiple sclerosis; particulate matter; spatial analysis; adverse effects; air pollution; cluster analysis; geographic mapping; multiple sclerosis; prevalence; risk factor, Air Pollution; Cluster Analysis; Environmental Exposure; Geographic Mapping; Humans; Iran; Multiple Sclerosis; Prevalence; Risk Factors |
Page Range: | pp. 233-238 |
Journal or Publication Title: | Neuroepidemiology |
Volume: | 43 |
Number: | 3-4 |
Publisher: | S. Karger AG |
Identification Number: | 10.1159/000368553 |
ISSN: | 02515350 |
Depositing User: | مهندس جمال محمودپور |
URI: | http://eprints.muk.ac.ir/id/eprint/1075 |
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