Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Effect of vitamin B6 versus propranolol on antipsychotic-induced akathisia: A pilot comparative double-blind study

(2018) Effect of vitamin B6 versus propranolol on antipsychotic-induced akathisia: A pilot comparative double-blind study. Iranian Journal of Pharmaceutical Research.

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Abstract

Akathisia is a common adverse effect of antipsychotic drugs and is characterized by subjective feelings of restlessness. First-line treatment usually consists of propranolol, a beta adrenergic antagonist. However, propranolol does not seem to be efficacious in up to 70 of patients. This study was aimed to evaluate the effect of vitamin B6 versus propranolol on antipsychotic-induced akathisia (AIA). This study was a comparative, double-blind, randomized trial. In the present study, 66 adult patients with antipsychotic-induced akathisia were enrolled and randomized into three groups, and received vitamin B6 300 mg/12 h or 600 mg/12 h or propranolol 20 mg/12 h. The diagnosis of AIA was made by clinical examination and its severity was assessed by the Barnes Akathisia Rating Scale. Fifty one patients completed 5 days of the trial. The results showed that there was no significant difference in BARS score among the different groups which means that vitamin B6 attenuated the AIA similar to propranolol. However, there wasn�t any significant difference between high or low dose of vitamin B6. In conclusion, the results of this trial suggest that vitamin B6 may be beneficial for ameliorating of antipsychotic-induced akathisia. © 2018 by School of Pharmacy Shaheed Beheshti University of Medical Sciences and Health Services.

Item Type: Article
Keywords: neuroleptic agent; propranolol; pyridoxine, adult; akathisia; Article; Barnes Akathisia Scale; bipolar disorder; comparative study; controlled study; data analysis; disease severity; double blind procedure; drug induced disease; female; follow up; human; male; observational study; outcome assessment; psychosis; randomized controlled trial; restlessness
Page Range: pp. 130-135
Journal or Publication Title: Iranian Journal of Pharmaceutical Research
Volume: 17
Number: Specia
Publisher: Iranian Journal of Pharmaceutical Research
ISSN: 17350328
Depositing User: مهندس جمال محمودپور
URI: http://eprints.muk.ac.ir/id/eprint/1089

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