Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Association of VDR gene polymorphisms with risk of relapsing-remitting multiple sclerosis in an Iranian Kurdish population

(2018) Association of VDR gene polymorphisms with risk of relapsing-remitting multiple sclerosis in an Iranian Kurdish population. International Journal of Neuroscience.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Purpose: The purpose of this study was to evaluate the association of VDR Apa-I, Bsm-I, Fok-I, Taq-I single nucleotide polymorphisms (SNPs) with multiple sclerosis (MS) risk in an Iranian Kurdish population. Materials and methods: A population including of 118 patients and 124 healthy matched controls were recruited to the study. Genotyping of the SNPs was accomplished using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: The frequency of allele T of Fok-I (P = 0.003) and allele C of Taq-I (P = 0.0003) was significantly different between case and control subjects and showed significant association with risk of MS (OR = 1.84, 95 CI = 1.23�2.76; OR = 1.98, 95 CI = 1.36�2.87, respectively). CT genotype (OR = 1.7, 95 CI = 1.05�2.99) of Fok-I and CC genotype (OR = 2.18, 95 CI = 1.05�4.52) of Taq-I showed a predisposing effect. Combined TT+TC vs. CC for Fok-I (OR = 2.15, 95 = CI 1.29�3.60) and combined CC+TC vs. TT for Taq-I (OR = 2.58, 95 CI 1.51�4.40) were susceptibility genotypes for MS. Apa-I and Bsm-I were not significantly associated with risk of MS (OR < 1, P > 0.05) and any genotypes in any genetic models were not significantly different between cases and controls (P > 0.05). Conclusion: As a result, Fok-I and Taq-I showed significant association with risk of MS, while Apa-I and Bsm-I were not observed to be related to the risk of the disease in this population. © 2017 Informa UK Limited, trading as Taylor & Francis Group.

Item Type: Article
Keywords: association study; Kurdish population; Multiple sclerosis; single nucleotide polymorphism; vitamin D receptor
Page Range: pp. 505-511
Journal or Publication Title: International Journal of Neuroscience
Volume: 128
Number: 6
Publisher: Taylor and Francis Ltd
Identification Number: 10.1080/00207454.2017.1398158
ISSN: 00207454
Depositing User: مهندس جمال محمودپور
URI: http://eprints.muk.ac.ir/id/eprint/1167

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