Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Single-nucleotide polymorphisms of TNFA and IL1 in allergic rhinitis

(2013) Single-nucleotide polymorphisms of TNFA and IL1 in allergic rhinitis. Journal of Investigational Allergology and Clinical Immunology.

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Background: Allergic rhinitis is a complex polygenic disorder of the upper respiratory tract. Given that proinfl ammatory cytokines such as tumor necrosis factor (TNF) and interleukin (IL) 1 seem to play a role in the development of allergic rhinitis, we evaluated the associations between various single-nucleotide polymorphisms (SNPs) of the TNF and IL1 genes in a case-control study. Methods: The study population comprised 98 patients with allergic rhinitis. Genotyping was performed using polymerase chain reaction with sequence-specific primers for 2 TNFA promoter variants (rs1800629 and rs361525), 1 variant in the promoter region of IL1A (rs1800587), 2 SNPs in the IL1B gene (rs16944 and rs1143634), 1 variant in the IL1 receptor (rs2234650), and 1 in IL1RA (rs315952). Results: Patients who were homozygous for the T allele of rs16944 in IL1B had an 8.1-fold greater risk of allergic rhinitis than those with the C allele. In TNFA, a significant relationship was also detected between rs1800629 and rs361525 and allergic rhinitis. Except for rs1800587 in IL1A and rs315952 in IL1RA, significant differences were found between the patient and control groups for all other SNPs. Conclusions: We found that allelic variants in the TNFA and IL1 genes were not only associated with the risk of developing allergic rhinitis, but also affected disease course and severity. © 2013 Esmon Publicidad.

Item Type: Article
Keywords: immunoglobulin E; interleukin 1; interleukin 1 receptor; interleukin 1 receptor alpha; interleukin 1alpha; interleukin 1beta; tumor necrosis factor alpha; unclassified drug, adolescent; allele; allergic rhinitis; article; case control study; cockroach; controlled study; Dermatophagoides; disease course; disease severity; eosinophil count; female; genotype; grass pollen; human; major clinical study; male; polymerase chain reaction; risk; single nucleotide polymorphism, Adolescent; Child; Child, Preschool; Female; Genotype; Haplotypes; Humans; Interleukin-1; Male; Polymorphism, Single Nucleotide; Rhinitis, Allergic, Perennial; Tumor Necrosis Factor-alpha
Page Range: pp. 455-461
Journal or Publication Title: Journal of Investigational Allergology and Clinical Immunology
Volume: 23
Number: 7
ISSN: 10189068
Depositing User: مهندس جمال محمودپور

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