Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Association of CTLA-4 gene 49A/G polymorphism with the incidence of type 1 diabetes mellitus in the Iranian Kurdish population

(2013) Association of CTLA-4 gene 49A/G polymorphism with the incidence of type 1 diabetes mellitus in the Iranian Kurdish population. Pakistan Journal of Biological Sciences.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) has an inhibitoiy function on T cells and is critical for the induction of peripheral tolerance. CTLA-4 +49 G allele affects the CTLA-4 function and has been reported to be correlated with a higher risk of various autoimmune diseases including type 1 diabetes (T1D). The present study was conducted to investigate the association between the polymorphism of the CTLA-4 exon 1+49 A/G and susceptibility to TID and type 2 diabetes (T2D) in Kurds living in Iranian Kurdistan. The+49 A/G polymorphism was analyzed in 60 patients with TID, 56 patients with T2D and 107 control subjects using PCR Single-strand Conformation Polymorphism (SSCP) and restriction fragment length polymorphism methods. All studied populations (TID, T2D and Controls) were inHardy-Weinberg equilibrium (p, 0.39, 0.94 and 0.89, respectively). Both+49 G allele (p = 0. 015, OR = 1. 86) and +49 A/G genotype frequencies (p = 0. 012, OR = 2. 31) were significantly higher in TID patients than control. There was significant over-representation of the G allele in female TID patients. No significant differences in +49 G allele and +49 A/G genotype frequencies were found between T2D and control subjects. SSCP analysis did not show new mutation in the amplified segment. The results of this study indicate that CTLA-4+49 A/G gene polymorphism confers genetic susceptibility to TID but not T2D in the Kurdish population living in Iranian Kurdistan and women cariying the +49 G allele are at greater risk of getting TID than men having the G allele. © 2013 Asian Network for Scientific Information.

Item Type: Article
Keywords: cytotoxic T lymphocyte antigen 4, Arab; article; case control study; ethnology; female; gene frequency; genetic predisposition; genetics; human; immunology; incidence; insulin dependent diabetes mellitus; Iran; male; non insulin dependent diabetes mellitus; phenotype; risk; risk factor; sex difference; single nucleotide polymorphism, Arabs; Case-Control Studies; CTLA-4 Antigen; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Incidence; Iran; Male; Odds Ratio; Phenotype; Polymorphism, Single Nucleotide; Risk Factors; Sex Factors
Page Range: pp. 1929-1935
Journal or Publication Title: Pakistan Journal of Biological Sciences
Volume: 16
Number: 24
Identification Number: 10.3923/pjbs.2013.1929.1935
ISSN: 10288880
Depositing User: مهندس جمال محمودپور
URI: http://eprints.muk.ac.ir/id/eprint/1275

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