Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Higher glycemic index and glycemic load diet is associated with increased risk of esophageal squamous cell carcinoma: A case-control study

(2013) Higher glycemic index and glycemic load diet is associated with increased risk of esophageal squamous cell carcinoma: A case-control study. Nutrition Research.

Full text not available from this repository.

Official URL:


Several studies have indicated the association between intake of foods high in dietary glycemic index (GI) and glycemic load (GL) with an increased risk of digestive tract cancers. We hypothesized that GI and GL may be associated with risk of esophageal squamous cell carcinoma (ESCC) in a high-risk population in Iran. In total, we interviewed 47 cases with incident of ESCC and 96 frequency-matched hospital controls, then calculated the average dietary GI and GL via a validated food frequency questionnaire. Dietary GL was calculated as a function of GI, carbohydrate content, and frequency of intake of certain foods. Dietary GI and GL levels were significantly higher among the ESCC cases compared with the controls (P < .05). After adjustment for potential confounders, those in the highest tertile of dietary GI had 2.95 times higher risk of ESCC compared with those in the lowest (95 confidence interval, 1.68-3.35; P for trend = .002). In addition, being in the highest tertile of dietary GL was positively associated with an ESCC risk (odds ratio, 3.49; 95 confidence interval, 2.98-4.41; P for trend = .001). Findings of the present study indicate that diets with high GI and GL might have potentially unfavorable effects on ESCC risk and suggest a possible role for excess circulating insulin and related insulin-like growth factor 1 in esophageal cancer development. © 2013 Elsevier Inc.

Item Type: Article
Keywords: insulin; somatomedin, adult; article; body mass; carbohydrate intake; clinical article; controlled study; diet; dietary intake; education; energy consumption; environmental factor; esophageal squamous cell carcinoma; female; food frequency questionnaire; gastroesophageal reflux; glycemic index; glycemic load; heredity; high risk population; histopathology; human; Iran; male; pathogenesis; priority journal; protein intake; risk factor; smoking; sugar intake, BMI; body mass index; Carbohydrate; Case control; CIs; confidence intervals; EC; ESCC; esophageal cancer; Esophageal squamous cell carcinoma; esophageal squamous cell carcinoma; FCT; FFQ; Fiber; food composition table; food frequency questionnaire; gastroesophageal reflux disease; GERD; GI; GL; Glycemic index; glycemic index; glycemic load; Glycemic load; IGF-1; insulin-like growth factor 1; odds ratios; ORs; US Department of Agriculture; USDA, Adult; Aged; Blood Glucose; Body Mass Index; Carcinoma, Squamous Cell; Case-Control Studies; Confidence Intervals; Diet; Dietary Carbohydrates; Esophageal Neoplasms; Female; Food Habits; Glycemic Index; Humans; Insulin; Iran; Logistic Models; Male; Middle Aged; Multivariate Analysis; Nutrition Assessment; Odds Ratio; Prevalence; Risk Factors
Page Range: pp. 719-725
Journal or Publication Title: Nutrition Research
Volume: 33
Number: 9
Identification Number: 10.1016/j.nutres.2013.06.002
ISSN: 02715317
Depositing User: مهندس جمال محمودپور

Actions (login required)

View Item View Item