Abstract

Many studies have recently shown that exercise-mediated lymphocyte apoptosis occurs in peripheral lymphocytes. However, many other studies did not confirm this notion. We aim to study the effect of two months adaptive aerobic exercise on CD95 expression on lymphocytes in healthy women. 24 healthy inactive women with 20.98± 3.14 average age were divided into 2 groups; the test group was performed 8-wk adaptive aerobic exercise completed a long moderate-intensity exercise consists 30 minutes training in day and control group completed 8-wk inactivity. Blood was collected immediately before and after 8-wk, after exhaustive exercise, and 24h after exhaustive test to determine CD95 expression on lymphocytes. CD95 expression on lymphocytes was determined by employing flow cytometry. No significant difference was detected in the amount of lymphocyte apoptosis between first and second stage in control group. In contrast, we found that the level of CD95 was significantly decreased after two months of adaptive exercise. Moreover, we observed that CD95 expression did not changed after exhausting exercise in both control and experimental groups. In conclusion, our data show that adaptive exercise reduces CD95 expression on lymphocytes, indicating that health activity might lead to decrease apoptosis of peripheral blood lymphocytes in active person in compare with inactive person. © IDOSI Publications, 2013.