Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Cutaneous and post kala-azar dermal leishmaniasis caused by Leishmania infantum in endemic areas of visceral leishmaniasis, northwestern Iran 2002-2011: A case series

(2013) Cutaneous and post kala-azar dermal leishmaniasis caused by Leishmania infantum in endemic areas of visceral leishmaniasis, northwestern Iran 2002-2011: A case series. Pathogens and Global Health.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Visceral leishmaniasis (VL) is endemic in Northwest and southern Iran. Reports of cutaneous leishmaniasis (CL) in Northwest areas are rare, and its etiological agents are unknown. In the current study, we report six CL and two post kala-azar dermal leishmaniasis (PKDL) cases caused by Leishmania infantum from endemic areas of VL in the Northwest. Smears were made from skin lesions of 30 suspected patients in 2002-2011, and CL was determined by microscopy or culture. Leishmania spp. were identified by nested-PCR assay. The disease was confirmed in 20 out of 30 (66) suspected patients by parasitological examinations. L. infantum was identified in eight and Leishmania major in 12 CL cases by nested-PCR. Cutaneous leishmaniasis patients infected with L. major had the history of travel to CL endemic areas. L. infantum antibodies were detected by direct agglutination test (DAT) at titers of 1:3200 in two cases with history of VL. Results of this study indicated that L. infantum is a causative agent of CL as well as PKDL in the VL endemic areas. © W. S. Maney & Son Ltd 2013.

Item Type: Article
Keywords: meglumine antimonate, agglutination test; article; child; clinical article; endemic disease; female; human; import disease; infant; Leishmania infantum; Leishmania major; male; molecular diagnosis; nonhuman; polymerase chain reaction; preschool child; serodiagnosis; skin defect; skin leishmaniasis; travel; visceral leishmaniasis, Agglutination Tests; Antibodies, Protozoan; Child, Preschool; Female; Humans; Infant; Iran; Leishmania infantum; Leishmaniasis, Mucocutaneous; Leishmaniasis, Visceral; Male; Microscopy; Parasitology; Polymerase Chain Reaction; Skin
Page Range: pp. 194-197
Journal or Publication Title: Pathogens and Global Health
Volume: 107
Number: 4
Identification Number: 10.1179/2047773213Y.0000000097
ISSN: 20477724
Depositing User: مهندس جمال محمودپور
URI: http://eprints.muk.ac.ir/id/eprint/1301

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