Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Detection of SHV type extended-spectrum B-lactamase and risk factors in pseudomonas aeruginosa clinical isolates

(2013) Detection of SHV type extended-spectrum B-lactamase and risk factors in pseudomonas aeruginosa clinical isolates. Pakistan Journal of Medical Sciences.

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Abstract

Objective: Pseudomonas aeruginosa is one of the most important causes of nosocomial infections and can acquire resistant to many antimicrobials, including β-lactams. The aim of this study was to detect the prevalence of SHV type extended-spectrum beta-lactamase (ESBL), antimicrobial resistance patterns of the P. aeroginusa and risk factors in hospitalized patients in two teaching hospitals in Sanandaj, Iran. Methodology: 123 P. aeruginosa were isolated from various clinical specimens. All samples were prepared for double-disk synergy test on the isolates for detection of ESBL. SHV was confirmed by PCR method. Risk factors were evaluated for infection due to P. aeruginosa. Results: The incidence of multiple drug resistance (MDR) in P. aeroginusa isolates was 3.85. The prevalence of ESBL-SHV gene was 10.57. Days of hospitalization (OR=14.34 CI95 2.87-25.8), ICU hospitalization (OR=3.4 CI95 1.24- 9.29), presence of catheter (OR=3.63 CI 95 1.34-9.84), use of antimicrobials within previous two weeks (OR=5.51 CI95 1.85-16.43) and use of ventilator (OR=3.7557 CI951.29-9) were risk factors for Pseudomonas nosocomial infection SHV positive ESBL. Conclusion: In this study Prevalence of ESBL, SHV gene and MDR in P. aeroginosa infection was lower than the prevalence reported from other studies in Iran and this indicated appropriate antimicrobial managements strategies and infection control. In addition, our research data indicate that risk factors such as use of ventilator, use of antimicrobials and ICU hospitalization can be effective in managing Pseudomonas infection.

Item Type: Article
Keywords: beta lactamase SHV; cefdinir; cefepime; cefotaxime; ceftazidime; ceftizoxime; ciprofloxacin; gentamicin; imipenem; nalidixic acid; norfloxacin; tetracycline, adult; aged; antibiotic resistance; article; artificial ventilation; bacterial gene; bacterial strain; bacterium isolate; catheterization; child; disease association; drug use; enzyme analysis; female; hospital infection; hospital patient; human; incidence; infection risk; intensive care unit; Iran; length of stay; major clinical study; male; multidrug resistance; nonhuman; polymerase chain reaction; preschool child; prevalence; Pseudomonas aeruginosa; Pseudomonas infection; risk assessment; SHV type extended spectrum beta lactamase gene; teaching hospital
Journal or Publication Title: Pakistan Journal of Medical Sciences
Volume: 29
Number: 3
Identification Number: 10.12669/pjms.293.3263
ISSN: 1682024X
Depositing User: مهندس جمال محمودپور
URI: http://eprints.muk.ac.ir/id/eprint/1306

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