Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

N-acetylcysteine provides analgesic effect in rats

(2013) N-acetylcysteine provides analgesic effect in rats. Journal of Isfahan Medical School.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Background: N-acetylcysteine (NAC), an acetylated variant of L-cysteine, is commonly used as an antidote for acetaminophen overdose and antimucolytic agent in chronic obstructive pulmonary disease. Recently, NAC is found to have anti-inflammatory and antioxidant properties. The aim of the present study was to evaluate the analgesic effect of NAC in rat model of plantar test. Methods: Male Wistar rats were randomly divided into six groups (n = 8). Animals received either normal saline (1 ml/kg) or different doses of NAC (200, 400, 600 mg/kg), morphine (10 mg/kg), or acetaminophen (50 mg/kg) intraperitoneally and the analgesic effect was assessed by plantar test apparatus at baseline, 30, 60 and 120 minutes after drug or vehicle administration. Findings: NAC provided significant analgesia at 30 minutes post-administration compared to control (normal saline) group while in the other time points, there were no significant differences between NAC and control group in plantar test. Conclusion: We found that NAC had analgesic effect and in order to find the involved mechanisms, further studies are needed.

Item Type: Article
Keywords: acetylcysteine; morphine; paracetamol; sodium chloride, analgesia; analgesic activity; animal experiment; article; controlled study; male; neurologic examination; nonhuman; plantar test; rat
Journal or Publication Title: Journal of Isfahan Medical School
Volume: 31
Number: 257
ISSN: 10277595
Depositing User: مهندس جمال محمودپور
URI: http://eprints.muk.ac.ir/id/eprint/1347

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