Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Inhibitory effects of methylsulfonylmethane on ventricular hypertrophy related gene expression

(2012) Inhibitory effects of methylsulfonylmethane on ventricular hypertrophy related gene expression. International Journal of Pharmacology.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Methylsulfonylmethane (MSM) is naturally accruing organic sulphur that is known as a potent antiinflammatory compound. The aim of this study was to investigate the effect of MSM on mRNA expressions of angiotensinogen, endothelin-1 (ET-1) and Transforming Growth Factor (TGF)-|3l in rats with monocrotaline (MCT)-induced pulmonary arterial hypertension. Wistar rats were randomly assigned to 38-days pretreatment or 28-days treatment. MSM was administered to either 10 days before or 14 days after a single dose of MCT. Right Ventricle (RV) tissue samples were obtained to evaluate changes in the inflammatory genes expression using RT-PCR assay. The expression levels of angiotensinogen, ET-1 and TGF-|3l significantly were reduced (p<0.01) at efficient dose of MSM in MCT-induced pulmonary arterial hypertensive rats. Results suggest that harmful effects of MCT induced PAH on the RV function could be attenuated by anti-inflammatory actions through the suppression of local RAAS along with associated growth-promoting factors TGF-βl and ET-1. © 2012 Asian Network for Scientific Information.

Item Type: Article
Keywords: angiotensinogen; antiinflammatory agent; dimethyl sulfone; endothelin 1; glyceraldehyde 3 phosphate dehydrogenase; glyceraldehyde 3 phosphate dehydrogenase (NADP); messenger RNA; monocrotaline; sulfur; transforming growth factor beta1, animal experiment; animal model; animal tissue; antiinflammatory activity; article; controlled study; drug effect; gene expression; heart right ventricle function; heart right ventricle hypertrophy; inflammation; male; nonhuman; nucleotide sequence; pulmonary hypertension; rat; renin angiotensin aldosterone system; reverse transcription polymerase chain reaction; Wistar rat
Page Range: pp. 647-651
Journal or Publication Title: International Journal of Pharmacology
Volume: 8
Number: 7
Identification Number: 10.3923/ijp.2012.647.651
ISSN: 18117775
Depositing User: مهندس جمال محمودپور
URI: http://eprints.muk.ac.ir/id/eprint/1389

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