Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Nutrient patterns and risk of esophageal squamous cell carcinoma: A case-control study

(2012) Nutrient patterns and risk of esophageal squamous cell carcinoma: A case-control study. Diseases of the Esophagus.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Although Iran is a high-risk country for esophageal squamous cell carcinoma (ESCC), the contribution of overall nutrient intakes to this high incidence rate is not yet clear. The aim of this study was to examine the association between nutrient patterns and risk of ESCC in Iran. Forty-seven patients with ESCC and 96 frequency-matched hospital controls underwent private interviews, and dietary habits were collected using a validated food-frequency questionnaire. Factor analysis was conducted and two major nutrient patterns were retained; factor 1 (high in pantothenic acid, vitamin C, potassium, vitamin B6, magnesium, folate, thiamin, copper, carbohydrate, vitamin K, niacin, α-tocopherol, zinc, total fiber, fluoride, and polyunsaturated fatty acids) and factor 2 (high in saturated fatty acid, biotin, selenium, monounsaturated fatty acids, riboflavin, sodium, fat, cholesterol, calcium, phosphorus, protein, iron, vitamin E, manganese, vitamin D, and vitamin B12). Factor 2 was inversely associated with ESCC (OR=0.06, 95 CI: 0.01-0.28; P=0.008), whereas no significant association was found for factor 1 (OR=0.45, 95 CI: 0.11-1.82). The results of the present study suggested a possible role for a nutrient pattern similar to factor 2 in reducing the risk of ESCC. © 2011, Wiley Periodicals, Inc. and the International Society for Diseases of the Esophagus.

Item Type: Article
Keywords: alpha tocopherol; ascorbic acid; biotin; calcium; carbohydrate; cholesterol; copper; cyanocobalamin; fat; fluoride; folic acid; iron; magnesium; manganese; nicotinic acid; pantothenic acid; phosphorus; polyunsaturated fatty acid; potassium; protein; pyridoxine; riboflavin; saturated fatty acid; selenium; sodium; thiamine; vitamin D; vitamin K group; zinc, adult; aged; article; caloric intake; cancer risk; case control study; clinical article; controlled study; dietary intake; esophageal squamous cell carcinoma; female; fiber; human; interview; Iran; male; nutrition; priority journal; questionnaire, Adult; Aged; Carcinoma, Squamous Cell; Case-Control Studies; Diet Surveys; Dietary Carbohydrates; Dietary Fats; Dietary Fiber; Esophageal Neoplasms; Factor Analysis, Statistical; Female; Food Habits; Humans; Iran; Male; Micronutrients; Middle Aged; Risk Factors
Page Range: pp. 442-448
Journal or Publication Title: Diseases of the Esophagus
Volume: 25
Number: 5
Identification Number: 10.1111/j.1442-2050.2011.01272.x
ISSN: 11208694
Depositing User: مهندس جمال محمودپور
URI: http://eprints.muk.ac.ir/id/eprint/1417

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