Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Antimicrobial effects of allicin and ketoconazole on Trichophyton rubrum under in vitro condition

(2012) Antimicrobial effects of allicin and ketoconazole on Trichophyton rubrum under in vitro condition. Brazilian Journal of Microbiology.

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Dermatophytosis is caused by a group of pathogenic fungi namely, dermatophytes, is among the most prevalent infectious diseases worldwide. Azole drugs are widely used in the treatment of dermatomycosis, but can cause various side effects and drug resistance to the patients. Hence, for solving this problem can be used from the plant extract as alternative for chemical drugs. Allicin is a pure bioactive compound isolated from garlic was tested for its potential as a treatment of dermatomycosis in this study. This study evaluated the in vitro efficacy of pure allicin against ten isolates of Trichophyton rubrum and the MIC 50 and MIC 90 ranged from 0.78-12.5 μg/ml for allicin. The results revealed that the order of efficacy based on the MICs values, all isolates showed almost comparable response to allicin and ketoconazole except for some isolates, at 28 °C for both 7 and 10 days incubation. Mann-Whitney test indicate that MICs at 7 days incubation was not observed a significant difference between the effects of allicin and ketoconazole (p > 0.05), but MICs at 10 days incubation, a significant difference was observed (p � 0.05). On the other side, time kill studies revealed that allicin used its fungicidal activity within 12-24 h of management in vitro as well as ketoconazole. In conclusion, allicin showed very good potential as an antifungal compound against mycoses-causing dermatophytes, almost the same as the synthetic drug ketoconazole. Therefore, this antifungal agent appears to be effective, safe and suitable alternative for the treatment of dermatomycosis.

Item Type: Article
Keywords: Allicin; Antifungal drugs; Dermatophytes; MIC (minimal inhibitory concentration
Page Range: pp. 786-792
Journal or Publication Title: Brazilian Journal of Microbiology
Volume: 43
Number: 2
Identification Number: 10.1590/S1517-83822012000200044
ISSN: 15178382
Depositing User: مهندس جمال محمودپور

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