Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Pretreatment with remifentanil is associated with less succinylcholine-induced fasciculation

(2010) Pretreatment with remifentanil is associated with less succinylcholine-induced fasciculation. Middle East Journal of Anesthesiology.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Background: Succinylcholine is a popular muscle relaxant and one of its most common side effects is muscle fasciculation. The purpose of this study was to evaluate the efficacy of remifentanil in preventing succinylcholine-induced fasciculation in patients undergoing general anesthesia. Methods: In a prospective, double blind study, 60 ASA I & II patients were randomly assigned into two groups (30 each) to receive either remifentanil1 μg/kg (Group R), or saline 3 ml (Group S) as a pretreatment agent, one minute before induction of general anesthesia by propofol, fentanyl, and 1.5 mg/kg succinylcholine. The duration and the intensity of fasciculation were assessed using a four-point rating scale. Data were analyzed by Mann-Whitney U-test, Fisher exact test and Student-t-test using SPSS software. Results: In the remifentanil group the duration (p<0.001) and the intensity (p<0.001) of fasciculation were lower compared to the saline group. However the incidence of bradycardia was higher in the remifentanil group in comparison to the group which received normal saline. Conclusions: Our findings indicate that remifentanil can reduce the duration and the intensity of succinylcholine induced fasciculation. However, it induces greater bradycardia.

Item Type: Article
Keywords: anesthetic agent; fentanyl; intravenous anesthetic agent; neuromuscular depolarizing agent; piperidine derivative; propofol; remifentanil; suxamethonium, adult; article; bradycardia; chemically induced disorder; clinical trial; controlled clinical trial; controlled study; double blind procedure; fasciculation; female; general anesthesia; hospitalization; human; male; methodology; middle aged; nonparametric test; prospective study; randomized controlled trial, Adult; Anesthesia, General; Anesthetics, Combined; Anesthetics, Intravenous; Bradycardia; Double-Blind Method; Fasciculation; Female; Fentanyl; Humans; Male; Middle Aged; Neuromuscular Depolarizing Agents; Piperidines; Propofol; Prospective Studies; Severity of Illness Index; Statistics, Nonparametric; Succinylcholine; Young Adult
Page Range: pp. 515-520
Journal or Publication Title: Middle East Journal of Anesthesiology
Volume: 20
Number: 4
ISSN: 05440440
Depositing User: مهندس جمال محمودپور
URI: http://eprints.muk.ac.ir/id/eprint/1556

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