Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Maternal plasma lipid concentrations in first trimester of pregnancy and risk of sever preeclapmsia

(2009) Maternal plasma lipid concentrations in first trimester of pregnancy and risk of sever preeclapmsia. Pakistan Journal of Medical Sciences.

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Objective: The role of abnormal lipid profile as a risk factor in pathology of pre-eclampsia is controversial. We investigated the relationship between early pregnancy plasma lipid concentrations and risk of severe pre-eclampsia. Methodology: It was a prospective cohort study, in which one thousand maternal blood samples were collected at first trimester of pregnancy. We selected 63 women who developed severe preeclampsia from the cohort and 280 normotensive as control group matched with pre-eclamptic group. Plasma lipid concentrations were measured enzymatically. Data was analyzed with student t-test, and Relative risk with 95 confidence interval was calculated. Results: The risk of severe preeclampsia among women with serum triglyceride level >175 mg/dl was 13.14 fold the ones with serum triglyceride level <100 (95 CI 1.84-265.4). Conclusion: This study has showed that early pregnancy dyslipidemia is associated with an increased risk of severe pre-eclampsia.

Item Type: Article
Keywords: triacylglycerol, adult; article; cohort analysis; colorimetry; controlled study; disease association; disease severity; dyslipidemia; enzyme assay; female; first trimester pregnancy; human; lipid blood level; major clinical study; maternal blood; maternal plasma; preeclampsia; prospective study; risk factor; Student t test; triacylglycerol blood level
Page Range: pp. 563-567
Journal or Publication Title: Pakistan Journal of Medical Sciences
Volume: 25
Number: 4
ISSN: 1682024X
Depositing User: مهندس جمال محمودپور

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