Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Comparison between molecular epidemiology, geographical regions and drug resistance in Mycobacterium tuberculosis strains isolated from Iranian and Afghan patients

(2006) Comparison between molecular epidemiology, geographical regions and drug resistance in Mycobacterium tuberculosis strains isolated from Iranian and Afghan patients. Chemotherapy.

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Abstract

The aim of this study was to determine the prevalence of drug-resistant tuberculosis (TB) and its associated risk factors. The susceptibilities of Mycobacterium tuberculosis isolates were tested against four first-line antituberculous drugs and were typed by spoligotyping. Spoligotyping of M. tuberculosis strains resulted in 95 different patterns that were divided into three evolutionary groups (1-3). Eighty-six (90) of the isolates had unique patterns that were reported for the first time. Interestingly, 9.4 of the strains belonged to the Beijing family. Multidrug resistance (MDR) was seen in group 1 of the evolutionary scenario. All M. tuberculosis isolates belonging to the Beijing family were associated with a resistance pattern. MDR was much higher in bacteria isolated from Afghan TB patients residing in Iran. Copyright © 2006 S. Karger AG.

Item Type: Article
Keywords: ethambutol; isoniazid; rifampicin; streptomycin, Afghanistan; antibiotic resistance; antibiotic sensitivity; article; bacterial strain; bacterium identification; bacterium isolate; bacterium spoligotyping; cell isolation; controlled study; evolutionary rate; geographic distribution; infection risk; Iran; molecular epidemiology; multidrug resistance; Mycobacterium tuberculosis; nonhuman; priority journal, Adult; Afghanistan; Anti-Bacterial Agents; Antibiotics, Antitubercular; Drug Resistance, Multiple, Bacterial; Epidemiology, Molecular; Ethambutol; Genotype; Humans; Iran; Isoniazid; Microbial Sensitivity Tests; Middle Aged; Mycobacterium tuberculosis; Prevalence; Rifampin; Risk Factors; Streptomycin; Tuberculosis, Multidrug-Resistant
Page Range: pp. 316-320
Journal or Publication Title: Chemotherapy
Volume: 52
Number: 6
Identification Number: 10.1159/000095971
ISSN: 00093157
Depositing User: مهندس جمال محمودپور
URI: http://eprints.muk.ac.ir/id/eprint/1633

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