Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

The effects of folate supplementation on lipid profiles among patients with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials

(2018) The effects of folate supplementation on lipid profiles among patients with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials. Diabetes and Metabolic Syndrome: Clinical Research and Reviews.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Background and objective: Although several studies have assessed the effect of folate supplementation on lipid profiles among patients with metabolic diseases, findings are inconsistent. This review of randomized controlled trials (RCTs) was conducted to summarize the evidence on the effects of folate supplementation on lipid profiles among patients with metabolic diseases. Methods: Randomized-controlled trials (RCTs) published in PubMed, EMBASE, Web of Science and Cochrane Library databases up to until 20 August 2017 were searched. Two review authors independently assessed study eligibility, extracted data, and evaluated risk of bias of included studies. Heterogeneity was measured with a Q-test and with I2 statistics. Data were pooled by using the fix or random-effect model based on the heterogeneity test results and expressed as standardized mean difference (SMD) with 95 confidence interval (CI). Results: A total of thirteen randomized controlled trials were included. Folate supplementation did not affect systolic blood pressure (SMD −0.87; 95 CI, −1.83, 0.09) and diastolic blood pressure (SMD −0.59; 95 CI, −1.55, 0.37), and lipid profiles including triglycerides (SMD 0.10; 95 CI, −0.42, 0.63), total- (SMD 0.06; 95 CI, −0.31, 0.43), HDL- (SMD 0.04; 95 CI, −0.36, 0.44), VLDL- (SMD 0.08; 95 CI, −0.24, 0.41), and LDL-cholesterol (SMD −0.14; 95 CI, −0.55, 0.28). Conclusions: Folate supplementation did not affect blood pressures and lipid profiles among patients with metabolic diseases. Additional prospective studies regarding the impact of folate supplementation on blood pressures and lipid profiles in patients with metabolic diseases are necessary. © 2017 Diabetes India

Item Type: Article
Keywords: folic acid; high density lipoprotein; high density lipoprotein cholesterol; lipid; low density lipoprotein cholesterol; triacylglycerol; very low density lipoprotein; very low density lipoprotein cholesterol; folic acid; lipid; vitamin B complex, diastolic blood pressure; human; lipid analysis; meta analysis; metabolic disorder; priority journal; randomized controlled trial (topic); Review; systematic review; systolic blood pressure; vitamin supplementation; blood; dietary supplement; metabolic disorder; prognosis; randomized controlled trial (topic), Dietary Supplements; Folic Acid; Humans; Lipids; Metabolic Diseases; Prognosis; Randomized Controlled Trials as Topic; Vitamin B Complex
Page Range: pp. 423-430
Journal or Publication Title: Diabetes and Metabolic Syndrome: Clinical Research and Reviews
Volume: 12
Number: 3
Publisher: Elsevier Ltd
Identification Number: 10.1016/j.dsx.2017.12.022
ISSN: 18714021
Depositing User: مهندس جمال محمودپور
URI: http://eprints.muk.ac.ir/id/eprint/1861

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