Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Well-tolerated oral cyclosporine in a case of hypersensitivity to parenteral cyclosporine in postallogeneic bone marrow transplantation

(2018) Well-tolerated oral cyclosporine in a case of hypersensitivity to parenteral cyclosporine in postallogeneic bone marrow transplantation. Indian Journal of Pharmacology.

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Cyclosporine is one of the main drugs used for the prophylaxis of graft versus host disease in bone marrow transplanted patients. Hypersensitivity reaction to intravenous cyclosporine is rare and might be due to its vehicle polyoxyethylated castor oil, Cremophor EL. The exact mechanism is unknown, but IgE and IgG antibodies, complement, and histamine release have been considered to play a role in the development of this reaction. Here, we describe a case of anaphylaxis to intravenous cyclosporine, which was developed in a 19-year-old Iranian female with acute myeloid leukemia who underwent allogeneic bone marrow transplantation from her sister. The corn oil-based soft gelatin capsule (Sandimmune®) was substituted with no reaction. Our observation along with the previous reports confirms the role of Cremophor EL in hypersensitivity reaction to cyclosporine, according to which, modifying the formulation of the intravenous (IV) form could be the solution for this problem. © 2018 Indian Journal of Pharmacology Published by Wolters Kluwer - Medknow.

Item Type: Article
Keywords: chlorpheniramine; corn oil; cremophor; cyclosporine; cytarabine; daunorubicin; gelatin; hydrocortisone; methotrexate; oxygen; prednisolone; cyclosporine; drug vehicle; glycerol; immunosuppressive agent, acute myeloid leukemia; adult; allogenic bone marrow transplantation; anaphylaxis; Article; case report; clinical article; consolidation chemotherapy; deterioration; drug formulation; drug hypersensitivity; drug tolerability; drug withdrawal; female; graft versus host reaction; human; Iranian people; leukemia remission; multiple cycle treatment; skin disease; young adult; analogs and derivatives; anaphylaxis; bone marrow transplantation; chemically induced; drug hypersensitivity; intravenous drug administration; oral drug administration, Administration, Intravenous; Administration, Oral; Adult; Anaphylaxis; Bone Marrow Transplantation; Cyclosporine; Drug Hypersensitivity; Female; Glycerol; Humans; Immunosuppressive Agents; Pharmaceutical Vehicles; Young Adult
Page Range: pp. 94-96
Journal or Publication Title: Indian Journal of Pharmacology
Volume: 50
Number: 2
Publisher: Wolters Kluwer Medknow Publications
Identification Number: 10.4103/ijp.IJP₉₉₁₈
ISSN: 02537613
Depositing User: مهندس جمال محمودپور

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