(2018) The effect of aqueous extract of Rosa damascena on formaldehyde-induced toxicity in mice testes. Pharmaceutical Biology.
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Abstract
Context: Rosa damascena L. (Rosaceae) (RD) essential oil and extracts are commonly used as a flavour in herbal medicine which increase libido. Previous studies have shown inhalation of RD flower’s oil increases libido and causes protective effects in formaldehyde (FA)-induced testicular damage. Objective: The protective effects of aqueous extract of RD on the male reproductive system of mice were examined following FA-induced damage. Materials and methods: Forty-eight adult NMRI male mice were randomly assigned to six groups (n = 8): control (normal saline, 10 mg/kg); RD40 (40 mg/kg, p.o.); FA treated (10 mg/kg of 10, i.p.) and FA+D treated at 10, 20 and 40 mg/kg (FA+D10), (FA+D20) and (FA+D40), respectively, for 40 days. At the end of treatment regimes, serum testosterone (T) level and the reproductive activity, viz. body/organ weights, testicular structure and sperm characteristics were studied. Results: Formaldehyde administration significantly decreased serum T level (p<0.001), testicular weight/volume, tubular diameter and sperm characteristics compared to the control group (p<0.05). RD (40mg/kg) administration in FA-treated mice significantly improved serum T level, testicular weight/histological structure, tubular diameter, Leydig cell number and epididymal sperm characteristics in comparison to its lower doses and the control group (p<0.05). Discussion and conclusions: We may conclude that RD flower extract can withstand effects of FA in the male reproductive system of mice possibly due to its antioxidative properties. © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Item Type: | Article |
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Keywords: | agents acting on the genital system; antioxidant; formaldehyde; plant extract; protective agent; Rosa damascena extract; testosterone; unclassified drug; plant extract; water, adult; animal cell; animal experiment; animal model; animal tissue; antioxidant activity; Article; body weight; cell count; controlled study; drug effect; epididymis; flower; histology; Leydig cell; male; morphology; mouse; nonhuman; organ weight; reproduction; reproductive toxicity; Rosa damascena; seminiferous tubule; sperm; testis injury; testis size; testis weight; testosterone blood level; treatment duration; animal; drug effect; isolation and purification; organ size; pathology; rose; testis; treatment outcome, Animals; Formaldehyde; Male; Mice; Organ Size; Plant Extracts; Rosa; Testis; Treatment Outcome; Water |
Page Range: | pp. 12-17 |
Journal or Publication Title: | Pharmaceutical Biology |
Volume: | 56 |
Number: | 1 |
Identification Number: | 10.1080/13880209.2017.1413663 |
Depositing User: | مهندس جمال محمودپور |
URI: | http://eprints.muk.ac.ir/id/eprint/1937 |
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