Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Serum levels of subfatin in patients with type 2 diabetes mellitus and its association with vascular adhesion molecules

(2018) Serum levels of subfatin in patients with type 2 diabetes mellitus and its association with vascular adhesion molecules. Archives of Physiology and Biochemistry.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Subfatin is a newly discovered adipokine with insulin-sensitizing properties. Studies reported conflicting data with regard to the circulating levels and expression of Subfatin in the context of type 2 diabetes mellitus (T2DM) and obesity. The present study was conducted on 52 patients with T2DM, 36 prediabetes subjects, and 50 controls. The serum levels of Subfatin, adhesion molecules were measured by the ELISA technique. The serum Subfatin was lower in the T2DM and prediabetes groups. The serum levels of adhesion molecules were higher in the T2DM group. In addition, Subfatin demonstrated lower levels in obese patients with T2DM in comparison to lean T2DM patients. Furthermore, Subfatin showed a negative association with vascular adhesion molecules in prediabetes subjects and the T2DM group. A decrease in the serum Subfatin in T2DM patients and prediabetes subjects, and its association with vascular adhesion molecules suggested the possible role of Subfatin in diabetes and endothelial dysfunction. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.

Item Type: Article
Keywords: E-selectin; endothelial dysfunction; ICAM-1; Subfatin/meteorin-like; VCAM-1
Journal or Publication Title: Archives of Physiology and Biochemistry
Publisher: Taylor and Francis Ltd
Identification Number: 10.1080/13813455.2018.1538248
ISSN: 13813455
Depositing User: مهندس جمال محمودپور
URI: http://eprints.muk.ac.ir/id/eprint/1940

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