Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Serum levels of CTRP3 in diabetic nephropathy and its relationship with insulin resistance and kidney function

(2019) Serum levels of CTRP3 in diabetic nephropathy and its relationship with insulin resistance and kidney function. PLoS ONE.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Background C1q TNF related protein 3 (CTRP3) is an adipokine secreted from adipose tissue. Previous studies have suggested that CTRP3 improves insulin sensitivity and reduces inflammation. Human studies have evaluated circulating levels of this adipokine in patients with diabetes mellitus (DM), diabetic retinopathy, metabolic syndrome, and coronary artery diseases. However, circulating levels of this adipokine in patients with diabetic nephropathy have not been evaluated. The present study aimed to assess serum levels of CTRP3 in patients with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (T2DM-NP) and its relationship with metabolic and inflammatory markers. Methods This cross-sectional study was performed on 55 controls, 54 patients with T2DM, and 55 patients with T2DM-NP. Serum levels of CTRP3, adiponectin, TNF-α, and IL-6 were measured by ELISA technique. Results Serum levels of CTRP3 were significantly lower in patients with T2DM (257.61 ± 69.79 ng/mL, p < 0.001) and T2DM-NP (222.03 ± 51.99 ng/mL, p < 0.001) compared to controls (328.17 ± 80.73 ng/mL), and those with T2DM-NP compared to T2DM group. CTRP3 was independently associated with HOMA-IR (r = -0.327, p < 0.05) and adiponectin (r = 0.436, p < 0.01) in T2DM group. In T2DM-NP patients, CTRP3 independently was associated with eGFR (r = 0.428, p < 0.01) and HOMA-IR (r = -0.436, p < 0.01). Furthermore, CTRP3 revealed a ability to differentiate T2DM-NP patients from controls (area under curve (95 confidence interval): 0.881 (0.820–0.943) and p < 0.001). Conclusion Decreased serum levels of CTRP3 in patients with T2DM and diabetic nephropathy and its association with pathologic mechanism in these patients suggested a possible role for CTRP3 in pathogenesis of diabetic nephropathy; nevertheless, further studies are required in this regard. © 2019 Moradi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Item Type: Article
Keywords: adipocytokine; adiponectin; alanine aminotransferase; aspartate aminotransferase; C1q tumor necrosis factor related protein 3; complement component C1q; creatinine; glucose; hemoglobin A1c; high density lipoprotein cholesterol; interleukin 6; low density lipoprotein cholesterol; triacylglycerol; tumor necrosis factor; unclassified drug, adult; alanine aminotransferase blood level; area under the curve; Article; aspartate aminotransferase blood level; body mass; case control study; cholesterol blood level; controlled study; cross-sectional study; diabetic nephropathy; enzyme linked immunosorbent assay; estimated glomerular filtration rate; female; glucose blood level; homeostasis model assessment; human; insulin resistance; kidney function; major clinical study; male; pathogenesis; population research; protein blood level; triacylglycerol blood level
Journal or Publication Title: PLoS ONE
Volume: 14
Number: 4
Publisher: Public Library of Science
Identification Number: 10.1371/journal.pone.0215617
ISSN: 19326203
Depositing User: مهندس جمال محمودپور
URI: http://eprints.muk.ac.ir/id/eprint/2041

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