Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Aloysia citriodora Palau (lemon verbena) for insomnia patients: A randomized, double-blind, placebo-controlled clinical trial of efficacy and safety

(2019) Aloysia citriodora Palau (lemon verbena) for insomnia patients: A randomized, double-blind, placebo-controlled clinical trial of efficacy and safety. Phytotherapy Research.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Aloysia citriodora (A. citriodora) has a long history of traditional use for sedation and treatment of insomnia in different societies. This study was carried out to assess the efficacy of A. citriodora in patients with insomnia. One hundred patients were randomly divided into two groups of A. citriodora (total essential oil 1.66 mg/10 ml and total amount of flavonoid in terms of quercetin 3.22 mg/10 ml of the syrup) and placebo. They were advised to use 10 cc of the syrups; an hour before the bedtime for a period of 4 weeks. Participants were assessed using Pittsburgh Sleep Quality Index (PSQI) and Insomnia Severity Index (ISI) questionnaires at the baseline and then 2 and 4 weeks after the enrollment. Mean scores of global PSQI and its four components including sleep latency, habitual sleep efficiency, daytime dysfunction, and subjective sleep quality and also ISI score in the A. citriodora group improved significantly after 4 weeks of treatment when compared with the placebo group (p < 0.001, for all of them). Also, improvement of global score of PSQI and ISI was observed in the intervention group as compared with the placebo group, 2 weeks after the enrollment (p < 0.001). The results of this study showed that oral intake of A. citriodora can be suggested as a complementary treatment for patients with insomnia. © 2018 John Wiley & Sons, Ltd.

Item Type: Article
Keywords: Aloysia citrodora extract; essential oil; flavonoid; hypnotic agent; plant extract; quercetin; unclassified drug; essential oil, adult; Aloysia citrodora; Article; controlled study; daytime somnolence; double blind procedure; drug effect; drug efficacy; drug mechanism; drug response; drug safety; female; follow up; human; insomnia; Insomnia Severity Index; intervention study; latent period; major clinical study; male; Pittsburgh Sleep Quality Index; randomized controlled trial; sleep quality; treatment outcome; chemistry; drug effect; insomnia; middle aged; questionnaire; sleep; Verbena (genus), Adult; Double-Blind Method; Female; Humans; Male; Middle Aged; Oils, Volatile; Sleep; Sleep Initiation and Maintenance Disorders; Surveys and Questionnaires; Treatment Outcome; Verbena
Page Range: pp. 350-359
Journal or Publication Title: Phytotherapy Research
Volume: 33
Number: 2
Identification Number: 10.1002/ptr.6228
Depositing User: مهندس جمال محمودپور
URI: http://eprints.muk.ac.ir/id/eprint/2099

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