Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Effects Of Saffron Supplementation On Inflammation And Metabolic Responses In Type 2 Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled Trial

(2019) Effects Of Saffron Supplementation On Inflammation And Metabolic Responses In Type 2 Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled Trial. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.

Full text not available from this repository.

Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Background: Type 2 diabetes (T2D) is accompanied by elevated inflammation, oxidative stress, hyperlipidemia and hyperglycemia which all contribute to cardiovascular disease pathogenesis. Saffron as a complementary medicine and source of antioxidants could play a role in alleviating diabetes and its complications. The aim of this study was to determine the effects of saffron supplementation as an adjunct therapy in T2D. Patients and methods: This randomized controlled trial included 80 T2D patients with a mean age of 54.1 years. Participants were randomly assigned into two groups to take either saffron tablets (100 mg/day; n=40) or placebo (n=40) for 12 weeks. Fasting blood samples were obtained at the beginning and after the intervention period to quantify glycemic factors, lipid profile, and biomarkers of inflammation and oxidative stress. Anthropometric indices and dietary intakes were also measured at baseline and at study end. Results: Compared with placebo, saffron supplementation resulted in significant decreases in waist circumference (p<0.001) and malondialdehyde (MDA) (p=0.001). There was no statistically significant difference in other indices, including anthropometric parameters, serum insulin, fasting blood glucose, HbA1c, insulin sensitivity indices, lipid profile, high-sensitivity C-reactive protein, total antioxidant capacity, and tumor necrosis factor-α between the study groups (p>0.05). Conclusion: Overall, 12 weeks of saffron supplementation in diabetic patients had beneficial effects on waist circumference and serum MDA levels. However, saffron did not influence other evaluated cardio metabolic risk markers in diabetic patients. © 2019 Ebrahimi et al. All rights reserved.

Item Type: Article
Keywords: antidiabetic agent; biological marker; C reactive protein; glibenclamide; hemoglobin A1c; insulin; malonaldehyde; metformin; natural product; placebo; saffron; tumor necrosis factor; unclassified drug, adult; aged; anthropometric parameters; antioxidant activity; Article; body height; body mass; body weight; clinical effectiveness; controlled study; dietary intake; double blind procedure; enzyme linked immunosorbent assay; evening dosage; female; glucose blood level; glycemic control; homeostasis model assessment; human; inflammation; insulin blood level; insulin sensitivity; lipid analysis; major clinical study; male; metabolic parameters; morning dosage; non insulin dependent diabetes mellitus; oxidative stress; prospective study; randomized controlled trial; treatment duration; treatment outcome; treatment response; waist circumference
Page Range: pp. 2107-2115
Journal or Publication Title: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Volume: 12
Identification Number: 10.2147/DMSO.S216666
Depositing User: مهندس جمال محمودپور
URI: http://eprints.muk.ac.ir/id/eprint/2122

Actions (login required)

View Item View Item