Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Medicinal plants in the prevention and treatment of colon cancer

(2019) Medicinal plants in the prevention and treatment of colon cancer. Oxidative Medicine and Cellular Longevity.

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The standard treatment for cancer is generally based on using cytotoxic drugs, radiotherapy, chemotherapy, and surgery. However, the use of traditional treatments has received attention in recent years. The aim of the present work was to provide an overview of medicinal plants effective on colon cancer with special emphasis on bioactive components and underlying mechanisms of action. Various literature databases, including Web of Science, PubMed, and Scopus, were used and English language articles were considered. Based on literature search, 172 experimental studies and 71 clinical cases on 190 plants were included. The results indicate that grape, soybean, green tea, garlic, olive, and pomegranate are the most effective plants against colon cancer. In these studies, fruits, seeds, leaves, and plant roots were used for in vitro and in vivo models. Various anticolon cancer mechanisms of these medicinal plants include induction of superoxide dismutase, reduction of DNA oxidation, induction of apoptosis by inducing a cell cycle arrest in S phase, reducing the expression of PI3K, P-Akt protein, and MMP as well; reduction of antiapoptotic Bcl-2 and Bcl-xL proteins, and decrease of proliferating cell nuclear antigen (PCNA), cyclin A, cyclin D1, cyclin B1 and cyclin E. Plant compounds also increase both the expression of the cell cycle inhibitors p53, p21, and p27, and the BAD, Bax, caspase 3, caspase 7, caspase 8, and caspase 9 proteins levels. In fact, purification of herbal compounds and demonstration of their efficacy in appropriate in vivo models, as well as clinical studies, may lead to alternative and effective ways of controlling and treating colon cancer. Copyright © 2019 Paola Aiello et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Item Type: Article
Keywords: Cell death; Cell proliferation; Chemotherapy; Diseases; Enzymes; Seed, Bcl-2 and Bcl-xl; Bioactive components; Cell-cycle arrest; English languages; Literature database; Literature search; Proliferating cell nuclear antigens; Super oxide dismutase, Plants (botany), antineoplastic agent; cyclin A; cyclin B1; cyclin D1; cyclin E; cycline; DNA; phosphatidylinositol 3 kinase; plant medicinal product; protein bcl 2; protein bcl xl; protein kinase B; superoxide dismutase, apoptosis; cancer prevention; cancer therapy; colon cancer; fruit; garlic; grape; human; medicinal plant; nonhuman; olive; oxidation; plant leaf; plant root; plant seed; pomegranate; protein expression; Review; S phase cell cycle checkpoint; soybean; systematic review; tea, Diseases; Documents; Enzymes; Plants; Processing; Proteins; Reduction
Journal or Publication Title: Oxidative Medicine and Cellular Longevity
Volume: 2019
Identification Number: 10.1155/2019/2075614
Depositing User: مهندس جمال محمودپور

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