Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

L-carnosine as an adjuvant to fluvoxamine in treatment of obsessive compulsive disorder: A randomized double-blind study

(2017) L-carnosine as an adjuvant to fluvoxamine in treatment of obsessive compulsive disorder: A randomized double-blind study. Human Psychopharmacology.

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Background: Dysregulation of glutamate is implicated in the pathogenesis of obsessive-compulsive disorder (OCD). Consistently, glutamate-modulating agents, such as riluzole and memantine have been used in OCD treatment. Previous research has identified some neuroprotective role for L-carnosine potentially via its modulatory effect on glutamate. Here, we assessed the efficacy of L-carnosine as adjuvant to fluvoxamine in OCD treatment. Methods: Forty-four patients diagnosed with moderate to severe OCD were recruited in a randomized double-blind trial. Patients received either L-carnosine or placebo as adjuvant to fluvoxamine for 10 weeks. The Yale- Brown Obsessive Compulsive Scale (Y-BOCS) was used for assessing the severity of symptoms at baseline and at weeks 4, 8, and 10. Results: General linear model repeated measure showed significant effects for Time × Treatment interaction on total Y-BOCS F (2.10, 88.42) = 8.66, p < 0.001, obsession F (1.88, 79.34) = 4.96, p = 0.01 and compulsion F (1.88, 79.11) = 4.57, p = 0.01. At week 10, the change from baseline in Y-BOCS scores was 8.86 ± 2.89 (mean ± SD) in the L-carnosine group compared to 5.86 ± 2.88 in the placebo group. Conclusion: L-carnosine results in significant reduction of obsessive-compulsive symptoms when used as an adjuvant to fluvoxamine. Copyright © 2017 John Wiley & Sons, Ltd.

Item Type: Article
Keywords: carnosine; fluvoxamine; placebo, adjuvant therapy; adult; Article; clinical article; comparative study; constipation; controlled study; dietary supplement; disease registry; double blind procedure; drug efficacy; drug potency; drug potentiation; female; headache; human; male; mental patient; nausea; neuroprotection; obsessive compulsive disorder; outcome assessment; priority journal; randomized controlled trial; side effect; sweating; treatment duration; xerostomia; Yale Brown Obsessive Compulsive Scale
Journal or Publication Title: Human Psychopharmacology
Volume: 32
Number: 4
Identification Number: 10.1002/hup.2584
Depositing User: مهندس مهدی شریفی

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