Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Effect of vitamin D receptor polymorphisms on plasma oxidative stress and apoptotic biomarkers among breast cancer survivors supplemented vitamin D3

(2020) Effect of vitamin D receptor polymorphisms on plasma oxidative stress and apoptotic biomarkers among breast cancer survivors supplemented vitamin D3. European Journal of Cancer Prevention.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

We investigated whether plasma oxidative stress and apoptotic biomarkers were associated with the VDR polymorphisms in breast cancer survivors supplemented with vitamin D3. Two hundred fourteen breast cancer survivors received 4000 IU of vitamin D3 daily for 12 weeks. Linear regression was used to analyze whether the effect of vitamin D3 supplementation on response variables was associated with the selected VDR single nucleotide polymorphisms executing by 'association' function in the R package 'SNPassoc'. Linear regression analyses adjusted for age, BMI and on-study plasma 25(OH)D changes indicated that the aa genotype of the ApaI codominant model (aa vs. AA):-0.21 (-0.39 to-0.03); recessive model (aa vs. AA and Aa):-0.20 (-0.37 to-0.03) and bb genotypes of the BsmI recessive model (bb vs. BB and Bb):-0.20 (-0.39 to-0.01) on VDR were associated with greater decrease in plasma Bcl2. Our findings indicated that, the Ff genotype of FokI was accompanied by higher increase in plasma MDA levels codominant model (Ff vs. FF): 0.64 (0.18-1.11); dominant model (ff and Ff vs. FF): 0.52 (0.09-0.05). This observed association was not remained statistically significant after correction for multiple testing. Haplotype score analyses revealed statistically significant association between the FokI BsmI ApaI haplotype and circulating MDA changes (P-value for global score = 0.001) after false-discovery rate correction. Our study suggests that genetic variations in the VDR do not powerfully modify the effects of vitamin D3 intake on biomarkers associated with antioxidant activity, oxidative stress and apoptosis in breast cancer survivors. © 2020 Lippincott Williams and Wilkins. All rights reserved.

Item Type: Article
Keywords: colecalciferol; malonaldehyde; protein bcl 2; vitamin D receptor, adult; aged; apoptosis; Article; body mass; breast cancer; cancer chemotherapy; cancer diagnosis; cancer radiotherapy; cancer surgery; cancer survivor; controlled study; drug overdose; female; genetic association; genetic variation; genotype; haplotype; human; linear regression analysis; major clinical study; oxidative stress; physical activity; priority journal; response variable; single nucleotide polymorphism; vitamin supplementation
Page Range: pp. 433-444
Journal or Publication Title: European Journal of Cancer Prevention
Volume: 29
Number: 5
Identification Number: 10.1097/CEJ.0000000000000576
Depositing User: مهندس جمال محمودپور
URI: http://eprints.muk.ac.ir/id/eprint/2250

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