Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Considerations around the SARS-CoV-2 Spike Protein with Particular Attention to COVID-19 Brain Infection and Neurological Symptoms

(2020) Considerations around the SARS-CoV-2 Spike Protein with Particular Attention to COVID-19 Brain Infection and Neurological Symptoms. ACS Chemical Neuroscience.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Spike protein (S protein) is the virus "key"to infect cells and is able to strongly bind to the human angiotensin-converting enzyme2 (ACE2), as has been reported. In fact, Spike structure and function is known to be highly important for cell infection as well as for entering the brain. Growing evidence indicates that different types of coronaviruses not only affect the respiratory system, but they might also invade the central nervous system (CNS). However, very little evidence has been so far reported on the presence of COVID-19 in the brain, and the potential exploitation, by this virus, of the lung to brain axis to reach neurons has not been completely understood. In this Article, we assessed the SARS-CoV and SARS-CoV-2 Spike protein sequence, structure, and electrostatic potential using computational approaches. Our results showed that the S proteins of SARS-CoV-2 and SARS-CoV are highly similar, sharing a sequence identity of 77. In addition, we found that the SARS-CoV-2 S protein is slightly more positively charged than that of SARS-CoV since it contains four more positively charged residues and five less negatively charged residues which may lead to an increased affinity to bind to negatively charged regions of other molecules through nonspecific and specific interactions. Analysis the S protein binding to the host ACE2 receptor showed a 30 higher binding energy for SARS-CoV-2 than for the SARS-CoV S protein. These results might be useful for understanding the mechanism of cell entry, blood-brain barrier crossing, and clinical features related to the CNS infection by SARS-CoV-2. Copyright © 2020 American Chemical Society.

Item Type: Article
Keywords: angiotensin converting enzyme 2; virus spike protein; vitronectin; coronavirus spike glycoprotein; spike protein, SARS-CoV-2, amino acid sequence; Article; binding affinity; blood brain barrier; brain infection; central nervous system infection; clinical feature; coronavirus disease 2019; human; molecular interaction; neurologic disease; nonhuman; priority journal; protein structure; Severe acute respiratory syndrome coronavirus 2; Betacoronavirus; brain; chemistry; Coronavirus infection; genetics; neurologic disease; pandemic; protein secondary structure; protein tertiary structure; virology; virus pneumonia, Amino Acid Sequence; Betacoronavirus; Brain; Coronavirus Infections; Humans; Nervous System Diseases; Pandemics; Pneumonia, Viral; Protein Structure, Secondary; Protein Structure, Tertiary; Spike Glycoprotein, Coronavirus
Page Range: pp. 2361-2369
Journal or Publication Title: ACS Chemical Neuroscience
Volume: 11
Number: 15
Publisher: American Chemical Society
Identification Number: 10.1021/acschemneuro.0c00373
ISSN: 19487193
Depositing User: مهندس جمال محمودپور
URI: http://eprints.muk.ac.ir/id/eprint/2259

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