Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Comparison of QuantiFERON-TB Gold In-Tube (QFT-GIT) and tuberculin skin test (TST) for diagnosis of latent tuberculosis in haemodialysis (HD) patients: A meta-analysis of κ estimates

(2017) Comparison of QuantiFERON-TB Gold In-Tube (QFT-GIT) and tuberculin skin test (TST) for diagnosis of latent tuberculosis in haemodialysis (HD) patients: A meta-analysis of κ estimates. Epidemiology and Infection.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Diagnosis of latent tuberculosis infection (LTBI) is a concern in haemodialysis (HD) patients. Many studies have compared QuantiFERON-TB Gold In-Tube (QFT-GIT) and tuberculin skin test (TST) for detecting LTBI and reported the κ statistic of agreement between QFT-GIT and TST in HD patients. The present study aimed to systematically review this literature and conduct meta-analysis of individual studies that estimated the κ between QFT-GIT with TST among HD patients. All relevant published studies that were available as full-text were obtained by searching Medline (1950), Web of Sciences (1945), Scopus (1973) through May 2016. The κ was re-estimated from the individual studies and pooled using random effect meta-analysis. Subgroup analysis and meta-regression were applied to evaluate the effect of Bacillus Calmette-Guérin (BCG) vaccination, TST cut-off points, quality of studies, sample size and age on variation of κ estimate. Eight studies involving 901 HD patients were included in meta-analysis. The pooled κ estimate was 0·28 (I 2 = 18·4, P = 0·239, 95 confidence intervals 0·22-0·34). The discordance of TST-/QFT-GIT+ was more than TST+/QFT-GIT-. History of BCG vaccination, TST cut-off points and age are related to variation of κ estimates. TST and QFT-GIT are not comparable in detecting LTBI in HD patients. The higher TST-/QFT-GIT+ ratio compared with TST+/QFT-GIT- ratio, may indicate the superiority of QFT-GIT over TST for detection LTBI in HD patients. © Copyright 2017 Cambridge University Press.

Item Type: Article
Keywords: Article; BCG vaccination; hemodialysis patient; human; intermethod comparison; latent tuberculosis; medical history; meta analysis; Mycobacterium tuberculosis test kit; sample size; sensitivity analysis; tuberculin test; hemodialysis; latent tuberculosis; microbiology; procedures; statistics and numerical data; tuberculin test, Humans; Latent Tuberculosis; Renal Dialysis; Tuberculin Test
Page Range: pp. 1824-1833
Journal or Publication Title: Epidemiology and Infection
Volume: 145
Number: 9
Publisher: Cambridge University Press
Identification Number: 10.1017/S0950268817000334
ISSN: 09502688
Depositing User: مهندس مهدی شریفی
URI: http://eprints.muk.ac.ir/id/eprint/226

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