Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Serum levels of C1q/TNF-related protein-3 in inflammatory bowel disease patients and its inverse association with inflammatory cytokines and insulin resistance

(2020) Serum levels of C1q/TNF-related protein-3 in inflammatory bowel disease patients and its inverse association with inflammatory cytokines and insulin resistance. IUBMB Life.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Ulcerative colitis (UC) and Crohn's disease (CD) are two major forms of inflammatory bowel disease (IBD), which is an inflammatory disease. Studies have shown that adipose tissue and inflammation play important roles in the pathogenesis of IBD. C1q/TNF-related protein-3 (CTRP3) is a newly discovered adipokine playing a substantial role during inflammatory process, and for the first time in the present study, serum levels of this adipokine were measured in the UC and CD patients. This case–control study included 70 control, 50 UC, and 50 CD patients who were diagnosed by standard criteria. Serum levels of adiponectin, IL-6, TNF-α, TGF-β, and CTRP3 were evaluated using ELISA kits. Serum levels of IL-6, TNF-α, and TGF-β elevated in the UC and CD patients compared with the controls while adiponectin and CTRP3 diminished in the patient's groups compared with the control. Furthermore, decrease in CTRP3 serum levels was associated with the risk of UC and CD diseases. Moreover, CTRP3 indicated negative correlation with BMI, FBS, insulin, homeostasis model assessment of insulin resistance, IL-6, TNF-α, and TGF-β and also a positive correlation with adiponectin in both the UC and CD patients. For the first time, the present study demonstrated lower levels of CTRP3 in the UC and CD patients. Decreased serum levels of CTRP3 and its inverse relationship with inflammatory cytokines and TGF-β levels suggested a possible role for CTRP3 in the pathogenesis of UC and CD diseases. © 2020 International Union of Biochemistry and Molecular Biology

Item Type: Article
Keywords: adipocytokine; adiponectin; c1q tumor necrosis factor alpha related protein 3; interleukin 6; transforming growth factor beta; tumor necrosis factor; unclassified drug, adipose tissue; adult; Article; body mass; case control study; controlled study; Crohn disease; disease association; female; homeostasis model assessment; human; inflammatory bowel disease; insulin resistance; major clinical study; male; pathogenesis; protein blood level; sex difference; ulcerative colitis
Page Range: pp. 1698-1704
Journal or Publication Title: IUBMB Life
Volume: 72
Number: 8
Publisher: Blackwell Publishing Ltd
Identification Number: 10.1002/iub.2293
ISSN: 15216543
Depositing User: مهندس جمال محمودپور
URI: http://eprints.muk.ac.ir/id/eprint/2273

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