Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Inverse correlation of soluble programmed cell death-1 ligand-1 (sPD-L1) with eosinophil count and clinical severity in allergic rhinitis patients

(2017) Inverse correlation of soluble programmed cell death-1 ligand-1 (sPD-L1) with eosinophil count and clinical severity in allergic rhinitis patients. Allergology International.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Background T-cell response outcome is determined by co-stimulatory/inhibitory signals. Programmed cell death-1 ligand-1 (PD-L1) is a member of these co-signaling molecules with known soluble form in human serum. Soluble PD-L1 (sPD-L1) is also recognized in patients with some types of malignancy or autoimmune disorders, though there are few studies on sPD-L1 roles in allergic diseases. The purpose of this survey was to evaluate the association between sPD-L1 levels with eosinophil count as well as disease severity in allergic rhinitis (AR) patients. Methods 90 patients with AR were selected. Disease severity was determined by a modified Allergic Rhinitis and its Impact on Asthma (ARIA) classification as mild, moderate and severe. Whole blood samples were collected. Then eosinophil count and serum sPD-L1 were detected by a hematologic analyzer and a commercial ELISA kit. Results 13 (14.44), 31 (34.44), and 46 (51.12) of patients had mild, moderate and severe disease, respectively. The mean levels of sPD-L1 and eosinophil count were ascertained 18.38 ± 14.42 ng/ml and 422.43 ± 262.26 cell/μl. A significant inverse correlation was determined between sPD-L1 levels and eosinophil count (r = −0.364, P < 0.001). Moreover, we detected a significant negative association between sPD-L1 levels and disease severity (r = −0.384, P < 0.001). Conclusions It is deduced that sPD-L1 can be used as a helpful marker to determine the severity of AR. Furthermore, this study indicated that sPD-L1 may have an inhibitory role in AR development, and its modulation may be considered as a useful accessory therapeutic approach for reduction of AR progression. © 2016 Japanese Society of Allergology

Item Type: Article
Keywords: allergen; programmed death 1 ligand 1; biological marker; programmed death 1 ligand 1, adult; allergic rhinitis; Article; conjunctivitis; correlation analysis; disease classification; disease severity; disease severity assessment; ELISA kit; enzyme linked immunosorbent assay; eosinophil count; female; human; major clinical study; male; nasal pruritus; nose obstruction; prick test; priority journal; protein blood level; pruritus; rhinorrhea; sneezing; blood; comorbidity; cross-sectional study; eosinophil; immunology; leukocyte count; phenotype; prognosis; Rhinitis, Allergic; severity of illness index; young adult, Adult; Allergens; Antigens, CD274; Biomarkers; Comorbidity; Cross-Sectional Studies; Eosinophils; Female; Humans; Leukocyte Count; Male; Phenotype; Prognosis; Rhinitis, Allergic; Severity of Illness Index; Young Adult
Page Range: pp. 326-331
Journal or Publication Title: Allergology International
Volume: 66
Number: 2
Publisher: Japanese Society of Allergology
Identification Number: 10.1016/j.alit.2016.08.008
ISSN: 13238930
Depositing User: مهندس مهدی شریفی
URI: http://eprints.muk.ac.ir/id/eprint/276

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