Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

The effect of menthol on acute experimental colitis in rats

(2017) The effect of menthol on acute experimental colitis in rats. European Journal of Pharmacology.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Menthol is an aromatic compound with high antiinflammatory activity. The purpose of the current research is to investigate the effectiveness of menthol on acetic acid induced acute colitis in rats. Animals were injected with menthol (20 and 50 and 80 mg/kg, i.p.) 24 h prior to induction of colitis for 3 consecutive days. Menthol at medium and higher doses similar to dexamethasone as a reference drug significantly reduced body weight loss, macroscopic damage score, ulcer area, colon weight, colon length and improved hematocrit in rats with colitis. The histopathological examination also confirmed anti-colitic effects of menthol. Menthol also reduced significantly the colonic levels of tumor necrosis factor-α (TNF-α), interleukin 1β (IL-1β), interleukin 6 (IL-6) and myeloperoxidase (MPO) activity in inflamed colons. Thus, the findings of the current study provide evidence that menthol may be beneficial in patients suffering from acute ulcerative colitis. © 2017 Elsevier B.V.

Item Type: Article
Keywords: dexamethasone; interleukin 1beta; interleukin 6; methanol; myeloperoxidase; tumor necrosis factor; cytokine; menthol; peroxidase, acute experimental colitis; acute experimental colitis; animal experiment; animal model; animal tissue; antiinflammatory activity; Article; colon length; colon weight; controlled study; dose response; drug effect; drug mechanism; enzyme activity; experimental colitis; general aspects of disease; hematocrit; intestine parameters; male; nonhuman; outcome assessment; priority journal; rat; ulcer area; weight change; acute disease; animal; blood; body weight; colitis; colon; disease model; drug effects; metabolism; pathology; Wistar rat, Acute Disease; Animals; Body Weight; Colitis; Colon; Cytokines; Disease Models, Animal; Hematocrit; Male; Menthol; Peroxidase; Rats; Rats, Wistar
Page Range: pp. 101-107
Journal or Publication Title: European Journal of Pharmacology
Volume: 805
Publisher: Elsevier B.V.
Identification Number: 10.1016/j.ejphar.2017.03.003
ISSN: 00142999
Depositing User: مهندس مهدی شریفی
URI: http://eprints.muk.ac.ir/id/eprint/338

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