Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Enriched cancer stem cells, dense stroma, and cold immunity: Interrelated events in pancreatic cancer

(2021) Enriched cancer stem cells, dense stroma, and cold immunity: Interrelated events in pancreatic cancer. Journal of Biochemical and Molecular Toxicology.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Cold tumors generally show low mutational burden and low infiltration of effector T cells. The pancreas, prostate, ovary, breast, and colon are placed into the category of cold tumors. In such tumors, effector T cells are either excluded from the tumor area or taken away from being in contact with tumor cells. The stromal reaction in the form of desmoplasia is important for the pathogenesis of tumors like the pancreas. Besides acting as a barrier for the penetration of drugs into the tumor area, the dense stroma presumably creates an immunosuppressive tumor microenvironment (TME), which accounts for low responses from tumor to immunotherapy. Cancer stem cells (CSCs) are an important part of the immunosuppressive complex within the TME. The presence of CSCs within the TME is related negatively to the activity of the antitumor immune system. Here, the question is how desmoplastic aggregates can influence the functionality of CSCs for promoting a cold pancreatic tumor immunity? This review is aimed at responding to this question, the disruption of which can be an effective strategy for improving responses from cold tumors to immunotherapy.

Item Type: Article
Keywords: ransforming growth factor, desmoplasia
Subjects: QZ Pathology > QZ 200-380 Neoplasms
Divisions: Research Vice-Chancellor Department > Cancer and Immunology Research Center
Journal or Publication Title: Journal of Biochemical and Molecular Toxicology
Journal Index: ISI
Publisher: John Wiley and Sons Inc
Identification Number: 10.1002/jbt.22708
ISSN: 10956670
Depositing User: مسعود رسول آبادی
URI: http://eprints.muk.ac.ir/id/eprint/4243

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