Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

The effects of pomegranate peel extract on the gene expressions of antioxidant enzymes in a rat model of alloxan-induced diabetes

(2021) The effects of pomegranate peel extract on the gene expressions of antioxidant enzymes in a rat model of alloxan-induced diabetes. Archives of Physiology and Biochemistry.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

This study was conducted to evaluate the anti-diabetic and antioxidant effects of hydroalcoholic pomegranate peel extract (APE) in alloxan-induced diabetes rat models. We divided 60 rats into the following six equal groups (n = 10): Healthy control; diabetic control (100 mg/kg alloxan); sham + glibenclamide (10 mg/kg); diabetic + glibenclamide (10 mg/kg); sham + APE (200 mg/kg) and diabetic + APE (200 mg/kg). After 8 weeks, kidneys were taken out for biochemical and molecular studies. Following APE treatment, biochemical parameters including malondialdehyde (MDA), and glutathione (GSH), glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD) significantly induced in the treated group as compared with the control group (p < 0.05). Also, gene expression of GPx (3-fold), CAT (2.6-fold), and SOD (1.5-fold) were increased as compared to controls (p < 0.05). Overall, our results indicated that pomegranate can be used as an antioxidant agent to reduce complications from diseases associated with oxidative stress.

Item Type: Article
Keywords: antioxidant enzymes, pomegranate peel extract, Diabetes
Subjects: WD Disorders of Systemic, Metabolic or Environmental Origin, etc. > WD 200-226 Metabolic Diseases
Divisions: Research Vice-Chancellor Department > Cancer and Immunology Research Center
Journal or Publication Title: Archives of Physiology and Biochemistry
Journal Index: ISI
Publisher: Taylor and Francis Ltd.
Identification Number: 10.1080/13813455.2021.1877308
ISSN: 13813455
Depositing User: مسعود رسول آبادی
URI: http://eprints.muk.ac.ir/id/eprint/4259

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