Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Prevalence of hepatitis c virus genotypes in hiv positive patients referring to the consultation center for behavioral diseases, Sanandaj, Iran

(2020) Prevalence of hepatitis c virus genotypes in hiv positive patients referring to the consultation center for behavioral diseases, Sanandaj, Iran. Iranian Journal of Microbiology.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Background and Objectives: Co-infection of hepatitis C virus (HCV) with human immunodeficiency virus (HIV) is increasing due to similar transmission pathways. Chronic HCV infection is the most common complication among HIV-infect-ed individuals. Information on the frequency of HCV infection on Iranian HIV-infected individuals is scarce. The aim of this study was the detection of HCV prevalence and genotypes among HIV-infected people in Sanandaj, Iran. Materials and Methods: In this cross-sectional study, whole blood samples were taken from 185 HIV positive individuals referring to Consultation Center for Behavioral Diseases, Sanandaj, Iran. The ELISA test was done on samples for anti-HCV antibodies. RNA was extracted from only anti-HCV antibody positive samples. An RT-PCR test was conducted to detect HCV RNA. Genotypes of HCV were detected by melting curve analysis by specific primers and probes. Test results and demographic information were analyzed by SPSS software. Results: The mean age of individuals was 39.3 ± 9.4 years. Out of 185 individuals 99 (53.5%) were positive for anti-HCV antibodies. Out of 99 antibody positive individuals, 44 had HCV RNA. Among 44 RNA positive individuals, genotypes and subtypes of HCV were as 26 (59.1%) 1a, 17 (38.6%) 3a and one (2.2%) 4. There was a significant association between an-ti-HCV antibody and demographic variables including, age, gender, occupation, and CD4+ T-cell count (p = 0.0001). Conclusion: The present study reveals that HIV/HCV co-infection is high in the study population. It is recommended similar studies should be done in other HIV infected populations for management of HIV/HCV co-infection. © 2020, Tehran University of Medical Sciences. All rights reserved.

Item Type: Article
Keywords: Hepatitis C virus; Human immunodeficiency virus
Divisions: Research Vice-Chancellor Department > Student Research Committee
Page Range: pp. 650-656
Journal or Publication Title: Iranian Journal of Microbiology
Journal Index: ISI, Pubmed, Scopus
Volume: 12
Number: 6
Publisher: Tehran University of Medical Sciences
ISSN: 20083289
Depositing User: دکتر علیرضا غریب
URI: http://eprints.muk.ac.ir/id/eprint/4535

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