Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

An overview of current knowledge in biological functions and potential theragnostic applications of exosomes

(2020) An overview of current knowledge in biological functions and potential theragnostic applications of exosomes. Chemistry and Physics of Lipids.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Exosomes are cup-shaped structures, made of two lipid layers. Their size is in the range of 30–150 nm. Exosomes are excreted to the extracellular space and function in local and systemic cellular communication. Based on their primary origins, they can contain substantial amounts of RNA, protein, and miRNA; the horizontal transfer of these contents significantly determines the exosome's biological effects. The endosomal origins of exosomes can be deduced based on their surface protein markers. The use of exosomes as a diagnostic biomarker and therapeutic tool, has numerous advantages because they do not pose risks such as aneuploidy and transplant rejection. This - overview highlights the recent findings in exosome development and current knowledge in exosome-based therapies

Item Type: Article
Keywords: Clinical applications; Exosomes; Extracellular vesicles
Divisions: Research Vice-Chancellor Department > Cellular and Molecular Research Center
Journal or Publication Title: Chemistry and Physics of Lipids
Journal Index: ISI, Pubmed, Scopus
Volume: 226
Publisher: Elsevier Ireland Ltd
Identification Number: 10.1016/j.chemphyslip.2019.104836
ISSN: 00093084
Depositing User: دکتر علیرضا غریب
URI: http://eprints.muk.ac.ir/id/eprint/4593

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