Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Comparison between brush cytology and forceps biopsy under fluoroscopic guidance for the diagnosis of proximal cholangiocarcinoma

(2020) Comparison between brush cytology and forceps biopsy under fluoroscopic guidance for the diagnosis of proximal cholangiocarcinoma. Middle East Journal of Digestive Diseases.

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Abstract

BACKGROUND Cholangiocarcinoma is the second most common malignant liver cancer. Its early diagnosis plays an important role in the success of treatment. The aim of this study was to compare the use of cold forceps biopsy without cholangioscopy with brush cytology in the diagnosis of cholangiocarcinoma. METHODS In this prospective study, we enrolled 19 patients. Endoscopic retrograde cholangi-opancreatography (ERCP) was performed for all individuals. Sampling was performed from the narrowing site using the brush method. Then, a cold forceps biopsy was performed under fluoroscopy. RESULTS The mean age of the patients was 63.31 ± 11.12 years and most of them were men (63.16 %). The brush cytology and the cold forceps biopsy diagnosed 31.85% and 68.42% of the samples as cholangiocarcinoma, respectively. According to the McNemar test, there was a statistically significant difference between the diagnostic results of the brush cytology and cold forceps biopsy. So that more cholangiocarcinoma cases were diagnosed using forceps biopsy (p = 0.016). No complications such as perforation, bleeding, cholangitis, and leakage were reported during the cold forceps procedure. CONCLUSION Cold forceps biopsy under fluoroscopy is better than cytology brush in the diagnosis of proximal cholangiocarcinoma. It is recommended to be used as a low-cost alternative in cases where cholangioscopy is not available.

Item Type: Article
Keywords: Biopsy Cholangiocarcinoma Cytology Diagnosis
Divisions: Research Vice-Chancellor Department > Social Determinants of Health Research Center
Page Range: pp. 246-251
Journal or Publication Title: Middle East Journal of Digestive Diseases
Journal Index: Pubmed, Scopus
Volume: 12
Number: 4
Publisher: Shriaz University of Medical Sciences
Identification Number: 10.34172/mejdd.2020.189
ISSN: 20085230
Depositing User: دکتر علیرضا غریب
URI: http://eprints.muk.ac.ir/id/eprint/4625

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