Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Polyethylenimine-graft-poly (maleic anhydride-alt-1-octadecene) coated Fe3O4 magnetic nanoparticles: promising targeted pH-sensitive system for curcumin delivery and MR imaging

(2020) Polyethylenimine-graft-poly (maleic anhydride-alt-1-octadecene) coated Fe3O4 magnetic nanoparticles: promising targeted pH-sensitive system for curcumin delivery and MR imaging. International Journal of Polymeric Materials and Polymeric Biomaterials.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

A theranostic amphiphilic nanocarrier based on iron oxide core with polyethyleneimine and poly(maleic anhydride-alt-1-octadecene) shell was synthesized, labeled with folic acid and loaded with Curcumin. Fe3O4@PIMF nanoparticles displayed a size of 20–30 nm with a shell thickness of 2–5 nm. Fe3O4@PIMF-CUR MNPs exhibited pH-responsive release behavior matched with Michaelis–Menten model. The MNPs showed more toxicity than free CUR against MCF-7 and Hela cells, while the drug-free carrier was safe against both cell lines. Hemolytic activity less than 1.5% in concentrations of <500 µg/mL indicated excellent blood compatibility. Appropriate negative signal enhancement in MRI confirmed the efficiency of the system for cancer theranostics

Item Type: Article
Keywords: Amphiphilic polymer; curcumin; magnetic nanoparticles; MRI; polyethyleneimine; targeted drug delivery; theranostic system
Subjects: WN Radiology. Diagnostic Imaging > WN 180-240 Diagnostic Imaging
Divisions: Education Vice-Chancellor Department > Faculty of Paramedical > Department of Radiology
Journal or Publication Title: International Journal of Polymeric Materials and Polymeric Biomaterials
Journal Index: ISI, Scopus
Publisher: Taylor and Francis Inc.
Identification Number: 10.1080/00914037.2020.1798435
ISSN: 00914037
Depositing User: دکتر علیرضا غریب
URI: http://eprints.muk.ac.ir/id/eprint/4664

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