(2020) Polyethylenimine-graft-poly (maleic anhydride-alt-1-octadecene) coated Fe3O4 magnetic nanoparticles: promising targeted pH-sensitive system for curcumin delivery and MR imaging. International Journal of Polymeric Materials and Polymeric Biomaterials.
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Abstract
A theranostic amphiphilic nanocarrier based on iron oxide core with polyethyleneimine and poly(maleic anhydride-alt-1-octadecene) shell was synthesized, labeled with folic acid and loaded with Curcumin. Fe3O4@PIMF nanoparticles displayed a size of 20–30 nm with a shell thickness of 2–5 nm. Fe3O4@PIMF-CUR MNPs exhibited pH-responsive release behavior matched with Michaelis–Menten model. The MNPs showed more toxicity than free CUR against MCF-7 and Hela cells, while the drug-free carrier was safe against both cell lines. Hemolytic activity less than 1.5% in concentrations of <500 µg/mL indicated excellent blood compatibility. Appropriate negative signal enhancement in MRI confirmed the efficiency of the system for cancer theranostics
| Item Type: | Article |
|---|---|
| Keywords: | Amphiphilic polymer; curcumin; magnetic nanoparticles; MRI; polyethyleneimine; targeted drug delivery; theranostic system |
| Subjects: | WN Radiology. Diagnostic Imaging > WN 180-240 Diagnostic Imaging |
| Divisions: | Education Vice-Chancellor Department > Faculty of Paramedical > Department of Radiology |
| Journal or Publication Title: | International Journal of Polymeric Materials and Polymeric Biomaterials |
| Journal Index: | ISI, Scopus |
| Publisher: | Taylor and Francis Inc. |
| Identification Number: | 10.1080/00914037.2020.1798435 |
| ISSN: | 00914037 |
| Depositing User: | دکتر علیرضا غریب |
| URI: | http://eprints.muk.ac.ir/id/eprint/4664 |
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