Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Hypoxia in solid tumors: a key promoter of cancer stem cell (CSC) resistance

(2020) Hypoxia in solid tumors: a key promoter of cancer stem cell (CSC) resistance. Journal of Cancer Research and Clinical Oncology.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Purpose: Cancer stem cells (CSCs) are highly tumorigenic cell types that reside within specific areas of tumor microenvironment (TME), and are endowed with self-renewal and resistance properties. Here, we aimed to discuss mechanisms involved in hypoxia-derived CSC resistance and targeting for effective cancer therapy. Results: Preferential localization within hypoxic niches would help CSCs develop adaptive mechanisms, mediated through the modification of responses to various stressors and, as a result, show a more aggressive behavior. Conclusion: Hypoxia, in fact, serves as a multi-tasking strategy to nurture CSCs with this adaptive capacity, complexing targeted therapies. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.

Item Type: Article
Keywords: Adaptation; Cancer stem cell (CSC;)Hypoxia; Hypoxia-inducible factor (HIF); Resistance Stemness; Tumor microenvironment (TME)
Subjects: QS Human Anatomy > QS504-532 Histology
Divisions: Research Vice-Chancellor Department > Cancer and Immunology Research Center
Page Range: pp. 19-31
Journal or Publication Title: Journal of Cancer Research and Clinical Oncology
Journal Index: ISI, Pubmed, Scopus
Volume: 146
Number: 1
Publisher: Springer
Identification Number: 10.1007/s00432-019-03080-1
ISSN: 01715216
Depositing User: دکتر علیرضا غریب
URI: http://eprints.muk.ac.ir/id/eprint/4670

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