(2020) Hypoxia in solid tumors: a key promoter of cancer stem cell (CSC) resistance. Journal of Cancer Research and Clinical Oncology.
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Abstract
Purpose: Cancer stem cells (CSCs) are highly tumorigenic cell types that reside within specific areas of tumor microenvironment (TME), and are endowed with self-renewal and resistance properties. Here, we aimed to discuss mechanisms involved in hypoxia-derived CSC resistance and targeting for effective cancer therapy. Results: Preferential localization within hypoxic niches would help CSCs develop adaptive mechanisms, mediated through the modification of responses to various stressors and, as a result, show a more aggressive behavior. Conclusion: Hypoxia, in fact, serves as a multi-tasking strategy to nurture CSCs with this adaptive capacity, complexing targeted therapies. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.
Item Type: | Article |
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Keywords: | Adaptation; Cancer stem cell (CSC;)Hypoxia; Hypoxia-inducible factor (HIF); Resistance Stemness; Tumor microenvironment (TME) |
Subjects: | QS Human Anatomy > QS504-532 Histology |
Divisions: | Research Vice-Chancellor Department > Cancer and Immunology Research Center |
Page Range: | pp. 19-31 |
Journal or Publication Title: | Journal of Cancer Research and Clinical Oncology |
Journal Index: | ISI, Pubmed, Scopus |
Volume: | 146 |
Number: | 1 |
Publisher: | Springer |
Identification Number: | 10.1007/s00432-019-03080-1 |
ISSN: | 01715216 |
Depositing User: | دکتر علیرضا غریب |
URI: | http://eprints.muk.ac.ir/id/eprint/4670 |
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