Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Resveratrol as an adjuvant for normal tissues protection and tumor sensitization

(2020) Resveratrol as an adjuvant for normal tissues protection and tumor sensitization. Current Cancer Drug Targets.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Cancer is one of the most complicated diseases in present-day medical science. Yearly, several studies suggest various strategies for preventing carcinogenesis. Furthermore, experiments for the treatment of cancer with low side effects are ongoing. Chemotherapy, targeted therapy, radiotherapy and immunotherapy are the most common non-invasive strategies for cancer treatment. One of the most challenging issues encountered with these modalities is low effectiveness, as well as normal tissue toxicity for chemo-radiation therapy. The use of some agents as adjuvants has been suggested to improve tumor responses and also alleviate normal tissue toxicity. Resveratrol, a natural flavonoid, has attracted a lot of attention for the management of both tumor and normal tissue responses to various modalities of cancer therapy. As an antioxidant and anti-inflammatory agent, in vitro and in vivo studies show that it is able to mitigate chemo-radiation toxicity in normal tissues. However, clinical studies to confirm the usage of resveratrol as a chemo-radioprotector are lacking. In addition, it can sensitize various types of cancer cells to both chemotherapy drugs and radiation. In recent years, some clinical studies suggested that resveratrol may have an effect on inducing cancer cell killing. Yet, clinical translation of resveratrol has not yielded desirable results for the combination of resveratrol with radiotherapy, targeted therapy or immunotherapy. In this paper, we review the potential role of resveratrol for preserving normal tissues and sensitization of cancer cells in combination with different cancer treatment modalities. © 2020 Bentham Science Publishers.

Item Type: Article
Keywords: Chemotherapy; Molecular targeted therapy; Neoplasm; Radiation Radiotherapy; Resveratrol; Tumor microenvironment
Subjects: QZ Pathology > QZ 200-380 Neoplasms
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Histology and Anatomy
Page Range: pp. 130-145
Journal or Publication Title: Current Cancer Drug Targets
Volume: 20
Number: 2
Publisher: Bentham Science Publishers
Identification Number: 10.2174/1568009619666191019143539
ISSN: 15680096
Depositing User: دکتر علیرضا غریب
URI: http://eprints.muk.ac.ir/id/eprint/4674

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