Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Is chronic toxoplasmosis a risk factor for diabetes mellitus? A systematic review and meta-analysis of case�control studies

(2016) Is chronic toxoplasmosis a risk factor for diabetes mellitus? A systematic review and meta-analysis of case�control studies. Brazilian Journal of Infectious Diseases.

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Introduction The global protozoan parasite, Toxoplasma gondii, infects many warm-blooded animals and humans by employing different transmission routes. There have been some recent studies on the probable relevance of infectious agents and diabetes. Therefore, we conducted a systematic review and meta-analysis to identify the possible association between chronic toxoplasmosis and diabetes mellitus. Methods This study was conducted following the general methodology recommended for systematic reviews and meta-analysis. Nine English literature databases (Google scholar, PubMed, Scopus, Web of science, Science Direct, Ovid, ProQuest, IngentaConnect, and Wiley Online Library) were searched, up to January 2016. Random effects model was used to determine odds ratios and their 95 confidence intervals. Results Our review resulted in a total of seven publications meeting the inclusion criteria. Because of significant heterogeneity, we estimated a common OR by a random effects model at 1.10 (95 CI = 0.13�9.57) with p = 0.929 and 2.39 (95 CI = 1.20�4.75) with p = 0.013 for type 1 and type 2 diabetes mellitus, respectively. Conclusion Despite the limitations such as low number of studies, this meta-analysis suggests chronic toxoplasmosis as a possible risk factor for type 2 DM. However, based on random effects model no statistically significant association was observed between T. gondii and type 1 DM. It is highly recommended for researchers to carry out more accurate studies aiming to better understand this association. © 2016 Sociedade Brasileira de Infectologia

Item Type: Article
Keywords: Article; case control study; diabetes mellitus; disease association; human; insulin dependent diabetes mellitus; non insulin dependent diabetes mellitus; risk factor; systematic review; Toxoplasma gondii; toxoplasmosis; chronic disease; complication; diabetes mellitus; meta analysis; parasitology; toxoplasmosis, Case-Control Studies; Chronic Disease; Diabetes Mellitus; Humans; Risk Factors; Toxoplasmosis
Page Range: pp. 605-609
Journal or Publication Title: Brazilian Journal of Infectious Diseases
Volume: 20
Number: 6
Publisher: Elsevier Editora Ltda
Identification Number: 10.1016/j.bjid.2016.09.002
ISSN: 14138670
Depositing User: مهندس جمال محمودپور

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