Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Curcumin: A dietary phytochemical for targeting the phenotype and function of dendritic cells

(2021) Curcumin: A dietary phytochemical for targeting the phenotype and function of dendritic cells. Current Medicinal Chemistry.


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Dendritic cells (DCs) are the most powerful antigen-presenting cells which link the innate and adaptive immune responses. Depending on the context, DCs initiate the immune responses or contribute to immune tolerance. Any disturbance in their phenotypes and functions may initiate inflammatory or autoimmune diseases. Hence, dysregulated DCs are the most attractive pharmacological target for the development of new therapies aiming at reducing their immuno-genicity and at enhancing their tolerogenicity. Curcumin is the polyphenolic phytochemical component of the spice turmeric with a wide range of pharmacological activities. It acts in several ways as a modulator of DCs and converts them into tolerogenic DCs. Tolerogenic DCs possess anti-inflammatory and immunomodulatory activities that regulate the immune responses in health and disease. Curcumin by blocking maturation markers, cytokines and chemokines expression, and disrupting the antigen-presenting machinery of DCs render them non-or hypo-responsive to im-munostimulants. It also reduces the expression of co-stimulatory and adhesion molecules on DCs and prevents them from both migration and antigen presentation but enhances their endocytosis capacity. Hence, curcumin causes DCs-inducing regulatory T cells and dampens CD4+ T helper 1 (Th1), Th2, and Th17 polarization. Inhibition of transcription factors such as NF-κB, AP-1, MAPKs (p38, JNK, ERK) and other intracellular signaling molecules such as JAK/STAT/SOCS provide a plausible explanation for most of these observations. In this review, we summarize the potential effects of curcumin on the phenotypes and functions of DCs as the key players in orches-tration, stimulation, and modulation of the immune responses. © 2021 Bentham Science Publishers.

Item Type: Article
Keywords: curcumin; phytochemical, dendritic cell; immunological tolerance; phenotype, Curcumin; Dendritic Cells; Immune Tolerance; Phenotype; Phytochemicals
Subjects: QT Physiology > QT104-172 Human Physiology
Divisions: Research Vice-Chancellor Department > Cellular and Molecular Research Center
Page Range: pp. 1549-1564
Journal or Publication Title: Current Medicinal Chemistry
Journal Index: ISI
Volume: 28
Number: 8
Publisher: Bentham Science Publishers
Identification Number: 10.2174/0929867327666200515101228
ISSN: 09298673
Depositing User: مسعود رسول آبادی

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