Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

A Novel Pharmacological Protective Role for Safranal in an Animal Model of Huntington�s Disease

(2021) A Novel Pharmacological Protective Role for Safranal in an Animal Model of Huntington�s Disease. Neurochemical Research.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Huntington�s disease (HD) is a progressive, neurodegenerative and inherited disease and recent years have witnessed the understanding of the cellular and molecular mechanisms related to HD. Safranal, an organic compound isolated from saffron, has been reported to have anti-apoptotic, anti-inflammatory and antioxidant activity and has studied in chronic and neurodegenerative disease. Therefore, this study was aimed to investigate the effect of safranal on 3-NP induced locomotor activity and biochemical alterations in rats. To this aim, 40 male Wistar rats weighting 250�300 g were divided into 5 groups (n = 8) including sham, 3-NP group (10 mg/kg) as control and treatment groups (3-NP + safranal 0.75, 1.5 and 3 mg/kg) in two weeks duration of treatment. Behavioral/movement assessments in addition to oxidant/antioxidant markers in rat cortex and striatum were evaluated in control and treatment groups. Here, we found that safranal significantly alleviated 3-NP-induced changes of body weight, rotarod activity, number of vacuous chewing movements (VCMs), and locomotor activity. In addition, brain tissue assessments in cortex and striatum revealed that safranal could prevent the elevation of nitrite and malondialdehyde (MDA) levels as well as decrease of superoxide dismutase (SOD), catalase activity and glutathione (GSH) induced by 3-NP. In conclusion our results showed that safranal prevented the motor dysfunction induced by 3-NP in animal model of Huntington�s disease. This effect might be due to its modulating effect on oxidants-antioxidant balance. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.

Item Type: Article
Keywords: 3-nitropropionic acid; Huntington�s disease; Locomotor activity; Saffron
Page Range: pp. 1372-1379
Journal or Publication Title: Neurochemical Research
Volume: 46
Number: 6
Publisher: Springer
Identification Number: 10.1007/s11064-021-03271-8
ISSN: 03643190
Depositing User: مسعود رسول آبادی
URI: http://eprints.muk.ac.ir/id/eprint/5175

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