Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Comparison of the effect of clomiphene- estradiol valerate vs letrozole on endometrial thickness, abortion and pregnancy rate in infertile women with polycystic ovarian syndrome

(2016) Comparison of the effect of clomiphene- estradiol valerate vs letrozole on endometrial thickness, abortion and pregnancy rate in infertile women with polycystic ovarian syndrome. Journal of Clinical and Diagnostic Research.

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Abstract

Introduction: Clomiphene citrate is the first-line therapy for ovulation induction in Polycystic Ovarian Syndrome (PCOS). This drug binds and blocks estrogen receptors and thought to have an anti estrogenic effect on endometrium volume thus may have adverse effect on fertility. Aim: This study aimed to compare the effect of Clomiphene citrate plus Estradiol Valerate with Letrozole on endometrial thickness, abortion and pregnancy rate in infertile women with PCOS undergoing ovulation induction. Materials and Methods: This was a randomized double blind clinical trial study on 100 women with PCOS with an endometrial thickness less than 7mm in spite of follicles greater than 18mm after administration of Clomiphene citrate 100mg/d from 3th to 7th day of menstruation. They were randomly divided in two groups. Group A received 100mg Clomiphene citrate from day 3 to day 7 of menstruation and 4 mg Estradiol Valerate after the 8th day of menstruation until 14th day. Group B treated by 5mg Letrozole from day 3 to 7 of menstruation with placebo from 8th to 14th day of menstruation. In both groups endometrial thickness was measured by transvaginal sonography in the 14th day of menstruation. Data were analysed using SPSS Ver.18.0. Results: The mean age was 30.34 years in group A and 29.62 years in group B (p=0.381). The number of infertility years in group A was 3.73 years and in group B was 3.85 years. There was no significant relationship statistically between the two groups in terms of mean age and infertility years (p=0.99). Endometrial thickness in group A was 7.26mm and in group B was 8.17 mm. Pregnancy rates in group A and group B was 32 and 16 respectively. There was significant relationship statistically between the two groups in terms of endometrial thickness and pregnancy rates (p=0.021 and p=0.05). There was no abortion in group A and 5 cases had abortion in group B, there was a significant relationship between the two groups statistically (p=0.028). Conclusion: Letrozole increased endometrial thickness and pregnancy rate in infertile women, therefore its administration is recommended. © 2016, Journal of Clinical and Diagnostic Research. All rights reserved.

Item Type: Article
Keywords: clomifene; estradiol valerate; letrozole, abortion; adult; Article; controlled clinical trial; controlled study; double blind procedure; endometrial thickness; female; female infertility; human; major clinical study; ovary polycystic disease; ovulation induction; pregnancy rate; transvaginal echography
Page Range: QC10-QC13
Journal or Publication Title: Journal of Clinical and Diagnostic Research
Volume: 10
Number: 8
Publisher: Journal of Clinical and Diagnostic Research
Identification Number: 10.7860/JCDR/2016/20954.8324
ISSN: 2249782X
Depositing User: مهندس جمال محمودپور
URI: http://eprints.muk.ac.ir/id/eprint/524

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