Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Radiation-induced nausea and vomiting: Is ABO blood group as important as radiation and patient-related factors? An observational study

(2016) Radiation-induced nausea and vomiting: Is ABO blood group as important as radiation and patient-related factors? An observational study. Medicine (United States).

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Despite the improvements in cancer screening and treatment, it still remains as one of the leading causes of mortality worldwide. Nausea and vomiting as the side effects of different cancer treatment modalities, such as radiotherapy, are multifactorial and could affect the treatment continuation and patient quality of life. Therefore, the aim of this study was to assess the possible linkage between ABO blood groups and radiation-induced nausea and vomiting (RINV), also its incidence and affecting factors. One hundred twenty-eight patients referring to Tohid hospital of Sanandaj, Iran, were selected and the patients and treatment-related factors were determined in a cross-sectional study. Patients' nausea and vomiting were recorded from the onset of treatment until 1 week after treatment accomplishment. Also, previous possible nausea and vomiting were recorded. The frequencies of nausea and vomiting and their peak time were examined during the treatment period. The association between ABO blood group and the incidence of radiotherapy-induced nausea and vomiting (RINV) were significant and it seems that A blood group patients are the most vulnerable individuals to these symptoms. The association between Rhesus antigen and the time of maximum severity of RINV may indicate that Rhesus antigen affects the time of maximum severity of RINV. The incidence of RINV was not affected by karnofsky performance status, but it was related to the severity of RINV. Furthermore, among the factors affecting the incidence of nausea and vomiting, nausea and vomiting during patient's previous chemotherapy, radiotherapy region, and background gastrointestinal disease were shown to be three important factors. In addition to familiar RINV-affecting factors, ABO blood group may play an important role and these results address the needs for further studies with larger sample size. Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved.

Item Type: Article
Keywords: antiemetic agent; rhesus antigen; blood group ABO system, adult; aged; Article; blood group ABO system; controlled study; cross-sectional study; disease severity; female; gastrointestinal disease; human; incidence; Iran; major clinical study; male; nonhuman; observational study; patient history of chemotherapy; patient history of radiotherapy; priority journal; radiation dose; radiation dose fractionation; radiation induced emesis; very elderly; adverse effects; analysis of variance; chi square distribution; middle aged; nausea; Neoplasms; pathology; pathophysiology; prognosis; risk assessment; treatment outcome; vomiting, ABO Blood-Group System; Adult; Aged; Analysis of Variance; Antiemetics; Chi-Square Distribution; Cross-Sectional Studies; Female; Humans; Incidence; Iran; Male; Middle Aged; Nausea; Neoplasms; Prognosis; Radiotherapy; Risk Assessment; Treatment Outcome; Vomiting
Journal or Publication Title: Medicine (United States)
Volume: 95
Number: 31
Publisher: Lippincott Williams and Wilkins
Identification Number: 10.1097/MD.0000000000004334
ISSN: 00257974
Depositing User: مهندس جمال محمودپور
URI: http://eprints.muk.ac.ir/id/eprint/525

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