Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Overall survival and prognostic factors prostate cancer in Kurdistan Province-Iran: a population-based study (2011-2018)

(2021) Overall survival and prognostic factors prostate cancer in Kurdistan Province-Iran: a population-based study (2011-2018). BMC cancer.

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/34876069

Abstract

BACKGROUND: The population-based survival rate is affected by the quality and effectiveness of health care systems. Overall, the survival of prostate cancer (PC) patients has improved over the past two decades worldwide. This study aimed to determine the overall survival rate and correlate it with the prognostic factors in patients with PC diagnosed in Kurdistan province. METHODS: In a retrospective cohort study, 410 PC patients registered in Kurdistan province population-based cancer registry from March 2011 to 2018 were recruited. Kaplan-Meier method and log-rank test were used to analyze the overall survival rates of PC patients. A Multivariate Cox regression model was used to determine adjusted hazard ratios for different variables. RESULTS: Of 410 patients with PC, 263 (64.1) died within seven years due to the disease. The 1, 3, and 5 years survival rates were 93, 64.1, and 40.7, respectively. According to the results of multiple Cox regression, the following factors were significantly related to PC survival: age at diagnosis (>/=81-years old) (HR=2.23, 95 CI: 1.23-4.42) and 71-80 years old was (HR=1.26, 95 CI: 1.12-2.31), occupation (employee) (HR=0.42, 95 CI: 0.20-0.87), educational level: academic (HR=0.78, 95 CI: 0.64-0.91), AJCC stage of disease (HR=2.18, 95 CI: 1.9-3.68), Gleason score >/= 9 (HR=7.12, 95 CI: 5.35-10.28), and Gleason score= 8 (HR=4.16, 95 CI: 2.50-6.93). There was less mortality rate among the patients who had received active care, radical prostatectomy, radiotherapy, combined treatment, and orchiectomy had a lower mortality rate than those who received no treatment (P<0.05). CONCLUSIONS: This study demonstrated that factors such as age at diagnosis, level of education, occupation, AJCC stage of disease, Gleason score, and type of treatments were influential factors in the survival of PC patients in Kurdistan province and needed more attention.

Item Type: Article
Keywords: Aged Aged, 80 and over Humans Iran/epidemiology Kaplan-Meier Estimate Male Middle Aged Neoplasm Grading/*mortality Prognosis Proportional Hazards Models Prostatectomy/mortality Prostatic Neoplasms/*mortality/pathology/therapy Registries Retrospective Studies Risk Factors Survival Rate Treatment Outcome Iran Kurdistan Population-Based Study Prostate Cancer Survival
Page Range: p. 1314
Journal or Publication Title: BMC cancer
Volume: 21
Number: 1
Depositing User: مهندس مهدی شریفی
URI: http://eprints.muk.ac.ir/id/eprint/5305

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