Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Effects of low-dose ketamine on succinylcholine-induced postoperative myalgia in outpatient surgeries: A randomized, double-blind study

(2016) Effects of low-dose ketamine on succinylcholine-induced postoperative myalgia in outpatient surgeries: A randomized, double-blind study. Journal of Pain Research.

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Objective: Despite the many complications of succinylcholine, it is still widely used as a superior muscle relaxant for rapid sequence induction. One of these complications is postoperative myalgia (POM). The aim of this study was to investigate the prophylactic effect of low-dose ketamine on the incidence and severity of POM. Materials and methods: In this double-blind clinical study, a total of 148 patients scheduled for general anesthesia were randomly divided into two equal groups. Initially, in Group K, 0.5 mg/kg of ketamine was injected intravenously, whereas in Group N, the same volume (5 mL) of normal saline was injected. Thereafter, anesthesia was induced in all patients, by injecting 1.5 mg/kg of fentanyl and 2 mg/kg of propofol intravenously. Following the loss of eyelid reflex, 1.5 mg/kg of succinylcholine was injected intravenously as a muscle relaxant and then the patients were intubated. POM was defined as a pain with no surgical interferences, and its intensity was graded based on a four-point scale. The incidence and severity of myalgia were assessed by a blinded observer 24 hours after surgery. Results: In terms of demographic data, the results of this study showed that there is no significant difference between patients in both groups (P>0.05). Overall, the incidence of POM in Group K was significantly less, when compared with Group N (P<0.05), but both groups were comparable based on the grade 2 of POM. After the induction of anesthesia, the systolic and diastolic blood pressure values were found to reduce in both groups (P<0.05). However, the changes were somehow similar, and repeated measures of variance analysis showed no significant difference in the two study groups (P>0.05). Conclusion: The addition of 0.5 mg/kg of ketamine to propofol for the induction of anesthesia can be effective in reducing the incidence of low-grade POM. © 2016 Nasseri and Arvien.

Item Type: Article
Keywords: ketamine; suxamethonium, adult; aged; Article; controlled study; diastolic blood pressure; double blind procedure; drug efficacy; drug safety; female; heart rate; human; incidence; low drug dose; major clinical study; male; myalgia; pain intensity; postoperative pain; randomized controlled trial; systolic blood pressure
Page Range: pp. 503-508
Journal or Publication Title: Journal of Pain Research
Volume: 9
Publisher: Dove Medical Press Ltd.
Identification Number: 10.2147/JPR.S106576
ISSN: 11787090
Depositing User: مهندس جمال محمودپور

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