Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Co-occurrence of Extended-Spectrum Beta-Lactamases in isolated Enterobacter spp. From patients specimens

(2016) Co-occurrence of Extended-Spectrum Beta-Lactamases in isolated Enterobacter spp. From patients specimens. Archives of Clinical Infectious Diseases.

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Background: Clinical significance of Extended-Spectrum Beta-Lactamases (ESBLs) production in Enterobacter spp. has not well been established. Objectives: This study was conducted to investigate the prevalence of ESBLs produced by Enterobacter spp. in clinical isolates. Materials and Methods: This descriptive cross-sectional study was performed during May 2010 to April 2012 in the city of Sanandaj, Kurdistan province, Iran. We did not include and directly contact the patient population, yet had access to two thousand patient specimens (urine, wound, respiratory tube, blood, cerebrospinal fluid and stool), which were collected from patients that had referred to various departments of two government hospitals of Toohid and Besat. As a result, 118 Enterobacter spp. isolates were identified and considered. The Clinical and laboratory standard institute (CLSI) Combined Disk Test (CDT) and polymerase chain reaction (PCR) were applied for detecting Enterobacter spp. Data were analyzed using the SPSS 11.5 software, Chi-square (x2) test and a Kappa coefficient (κ) (P < 0.05). Results: Out of 118 Enterobacter spp. isolates, 31.36 were Enterobacter aerogenes (E. aerogenes), 20.34 Enterobacter agglomerans (E. agglomerans), 12.71 Enterobacter cloacae (E. cloacae), and 33.90 were other Enterobacter spp. All 118 (100) Enterobacter isolates produced ESBLs. In the detection of ESBLs, CDT and PCR results were similar to each other and all 118 Enterobacter spp. were ESBLs producers (κ = 1). Conclusions: According to the results, most of the Enterobacter spp. produced ESBLs and were Cefotaxime-M (CTX-M) enzyme carriers. Guidelines and appropriate use of antibiotics are necessary to avoid the production of ESBLs. © 2016, Infectious Diseases and Tropical Medicine Research Center.

Item Type: Article
Keywords: antibiotic agent; cefotaxime; cefotaxime plus clavulanic acid; ceftazidime; ceftazidime plus clavulanic acid; extended spectrum beta lactamase; oxacillinase; unclassified drug, Article; bacterium identification; bacterium isolation; blood sampling; cerebrospinal fluid; combined disk test; controlled study; cross-sectional study; descriptive research; Enterobacter; Enterobacter aerogenes; Enterobacter cloacae; enzyme synthesis; feces; human; human tissue; intermethod comparison; laboratory test; major clinical study; minimum inhibitory concentration; nonhuman; Pantoea agglomerans; phenotype; polymerase chain reaction; prevalence; sampling; strain difference; urine; wound
Journal or Publication Title: Archives of Clinical Infectious Diseases
Volume: 11
Number: 3
Publisher: Kowsar Medical Publishing Company
Identification Number: 10.5812/archcid.26837
ISSN: 23452641
Depositing User: مهندس جمال محمودپور

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