Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Macrophage-Mediated Inflammation in Skin Wound Healing

(2022) Macrophage-Mediated Inflammation in Skin Wound Healing. Cells.

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Macrophages are key immune cells that respond to infections, and modulate pathophysiological conditions such as wound healing. By possessing phagocytic activities and through the secretion of cytokines and growth factors, macrophages are pivotal orchestrators of inflammation, fibrosis, and wound repair. Macrophages orchestrate the process of wound healing through the transitioning from predominantly pro-inflammatory (M1-like phenotypes), which present early post-injury, to anti-inflammatory (M2-like phenotypes), which appear later to modulate skin repair and wound closure. In this review, different cellular and molecular aspects of macrophage-mediated skin wound healing are discussed, alongside important aspects such as macrophage subtypes, metabolism, plasticity, and epigenetics. We also highlight previous studies demonstrating interactions between macrophages and these factors for optimal wound healing. Understanding and harnessing the activity and capability of macrophages may help to advance new approaches for improving healing of the skin.

Item Type: Article
Keywords: Cytokines/metabolism Humans Inflammation/metabolism *Macrophages/metabolism Skin *Wound Healing/physiology inflammation macrophages wound healing
Journal or Publication Title: Cells
Volume: 11
Number: 19
Depositing User: مهندس مهدی شریفی

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